InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: MLH1

Summary

InnateDB Protein

IDBP-696883.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MLH1

Protein Name

Uncharacterized protein

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000022288

InnateDB Gene

IDBG-644253 (MLH1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 130 interaction(s) predicted by orthology.

Predicted by orthology
Total	130 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003697	single-stranded DNA binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016887	ATPase activity
GO:0030983	mismatched DNA binding
GO:0032137	guanine/thymine mispair binding
GO:0032407	MutSalpha complex binding
GO:0043566	structure-specific DNA binding

Biological Process

GO:0000289	nuclear-transcribed mRNA poly(A) tail shortening
GO:0000712	resolution of meiotic recombination intermediates
GO:0002204	somatic recombination of immunoglobulin genes involved in immune response
GO:0006200	ATP catabolic process
GO:0006281	DNA repair
GO:0006298	mismatch repair
GO:0006303	double-strand break repair via nonhomologous end joining
GO:0006974	cellular response to DNA damage stimulus
GO:0007060	male meiosis chromosome segregation
GO:0007129	synapsis
GO:0007131	reciprocal meiotic recombination
GO:0007140	male meiosis
GO:0007283	spermatogenesis
GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage
GO:0016446	somatic hypermutation of immunoglobulin genes
GO:0016447	somatic recombination of immunoglobulin gene segments
GO:0043060	meiotic metaphase I plate congression
GO:0045132	meiotic chromosome segregation
GO:0045190	isotype switching
GO:0045950	negative regulation of mitotic recombination
GO:0048477	oogenesis
GO:0051257	spindle midzone assembly involved in meiosis

Cellular Component

GO:0000793	condensed chromosome
GO:0000794	condensed nuclear chromosome
GO:0000795	synaptonemal complex
GO:0001673	male germ cell nucleus
GO:0005634	nucleus
GO:0005694	chromosome
GO:0005712	chiasma
GO:0016020	membrane
GO:0032300	mismatch repair complex
GO:0032389	MutLalpha complex

Protein Structure and Domains

PDB ID

InterPro

IPR002099 DNA mismatch repair protein family
IPR003594 Histidine kinase-like ATPase, C-terminal domain
IPR013507 DNA mismatch repair protein, C-terminal
IPR020568 Ribosomal protein S5 domain 2-type fold

PFAM

PF02518
PF13581
PF01119

PRINTS

PIRSF

SMART

SM00387

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite