InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: MLH1

Summary

InnateDB Gene

IDBG-644253.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MLH1

Gene Name

DNA mismatch repair protein Mlh1

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000016758

Encoded Proteins

IDBP-696883

Uncharacterized protein

IDBP-696884

Uncharacterized protein

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000076242:
This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). It is a human homolog of the E. coli DNA mismatch repair gene mutL, consistent with the characteristic alterations in microsatellite sequences (RER+phenotype) found in HNPCC. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described, but their full-length natures have not been determined.[provided by RefSeq, Nov 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 22:10492112-10585992

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000022288	ENSBTAP00000022288
ENSBTAT00000048965	ENSBTAP00000045916

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 130 interaction(s) predicted by orthology.

Predicted by orthology
Total	130 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003697	single-stranded DNA binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016887	ATPase activity
GO:0030983	mismatched DNA binding
GO:0032137	guanine/thymine mispair binding
GO:0032407	MutSalpha complex binding
GO:0043566	structure-specific DNA binding

Biological Process

GO:0000289	nuclear-transcribed mRNA poly(A) tail shortening
GO:0000712	resolution of meiotic recombination intermediates
GO:0002204	somatic recombination of immunoglobulin genes involved in immune response
GO:0006200	ATP catabolic process
GO:0006281	DNA repair
GO:0006298	mismatch repair
GO:0006303	double-strand break repair via nonhomologous end joining
GO:0006974	cellular response to DNA damage stimulus
GO:0007060	male meiosis chromosome segregation
GO:0007129	synapsis
GO:0007131	reciprocal meiotic recombination
GO:0007140	male meiosis
GO:0007283	spermatogenesis
GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage
GO:0016446	somatic hypermutation of immunoglobulin genes
GO:0016447	somatic recombination of immunoglobulin gene segments
GO:0043060	meiotic metaphase I plate congression
GO:0045132	meiotic chromosome segregation
GO:0045190	isotype switching
GO:0045950	negative regulation of mitotic recombination
GO:0048477	oogenesis
GO:0051257	spindle midzone assembly involved in meiosis

Cellular Component

GO:0000793	condensed chromosome
GO:0000794	condensed nuclear chromosome
GO:0000795	synaptonemal complex
GO:0001673	male germ cell nucleus
GO:0005634	nucleus
GO:0005694	chromosome
GO:0005712	chiasma
GO:0016020	membrane
GO:0032300	mismatch repair complex
GO:0032389	MutLalpha complex