Version 5.4
Bos taurus Protein: PLCD1
Summary
InnateDB Protein IDBP-696923.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PLCD1
Protein Name 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta-1
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000049395
InnateDB Gene IDBG-644292 (PLCD1)
Protein Structure
UniProt Annotation
Function The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. Essential for trophoblast and placental development.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001786 phosphatidylserine binding
GO:0004435 phosphatidylinositol phospholipase C activity
GO:0004629 phospholipase C activity
GO:0004871 signal transducer activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0008081 phosphoric diester hydrolase activity
GO:0016787 hydrolase activity
GO:0032794 GTPase activating protein binding
GO:0046872 metal ion binding
GO:0070300 phosphatidic acid binding
GO:1901981 phosphatidylinositol phosphate binding
Biological Process
GO:0001525 angiogenesis
GO:0006629 lipid metabolic process
GO:0007165 signal transduction
GO:0016042 lipid catabolic process
GO:0035556 intracellular signal transduction
GO:0042127 regulation of cell proliferation
GO:0060716 labyrinthine layer blood vessel development
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR000008 C2 domain
IPR000909 Phospholipase C, phosphatidylinositol-specific , X domain
IPR001192 Phosphoinositide phospholipase C family
IPR001711 Phospholipase C, phosphatidylinositol-specific, Y domain
IPR001849 Pleckstrin homology domain
IPR002048 EF-hand domain
IPR015359 Phospholipase C, phosphoinositol-specific, EF-hand-like
IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain
PFAM PF00168
PF00388
PF00387
PF00169
PF00036
PF13202
PF13405
PF09279
PRINTS PR00360
PR00390
PIRSF
SMART SM00239
SM00148
SM00149
SM00233
SM00054
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P10895
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 790012
UniGene Bt.90659
RefSeq NP_001075045
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC133304 M20638
GenPept AAA30710 AAI33305

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca