InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: PLCD1

Summary

InnateDB Gene

IDBG-644292.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PLCD1

Gene Name

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000037726

Encoded Proteins

IDBP-696923

1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta-1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000187091:
This gene encodes a member of the phospholipase C family. Phospholipase C isozymes play critical roles in intracellular signal transduction by catalyzing the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) into the second messengers diacylglycerol (DAG) and inositol triphosphate (IP3). The encoded protein functions as a tumor suppressor in several types of cancer, and mutations in this gene are a cause of hereditary leukonychia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 22:11497086-11518465

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000052073

ENSBTAP00000049395

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001786	phosphatidylserine binding
GO:0004435	phosphatidylinositol phospholipase C activity
GO:0004629	phospholipase C activity
GO:0004871	signal transducer activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0008081	phosphoric diester hydrolase activity
GO:0016787	hydrolase activity
GO:0032794	GTPase activating protein binding
GO:0046872	metal ion binding
GO:0070300	phosphatidic acid binding
GO:1901981	phosphatidylinositol phosphate binding

Biological Process

GO:0001525	angiogenesis
GO:0006629	lipid metabolic process
GO:0007165	signal transduction
GO:0016042	lipid catabolic process
GO:0035556	intracellular signal transduction
GO:0042127	regulation of cell proliferation
GO:0060716	labyrinthine layer blood vessel development