InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: PIAS4

Summary

InnateDB Protein

IDBP-696953.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PIAS4

Protein Name

E3 SUMO-protein ligase PIAS4

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000001000

InnateDB Gene

IDBG-644320 (PIAS4)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 78 interaction(s) predicted by orthology.

Predicted by orthology
Total	78 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0019789	SUMO ligase activity
GO:0031625	ubiquitin protein ligase binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0032088	negative regulation of NF-kappaB transcription factor activity
GO:0033235	positive regulation of protein sumoylation
GO:0045892	negative regulation of transcription, DNA-templated
GO:1902174	positive regulation of keratinocyte apoptotic process
GO:1902231	positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0016363	nuclear matrix

Protein Structure and Domains

PDB ID

InterPro

IPR003034 SAP domain
IPR004181 Zinc finger, MIZ-type

PFAM

PF02037
PF02891

PRINTS

PIRSF

SMART

SM00513

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

A4FV15

UniProt Splice Variant

Entrez Gene

534722

UniGene

Bt.48545

RefSeq

NP_001076951

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC123606 DAAA02019628

GenPept

AAI23607