InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: PIAS4

Summary

InnateDB Gene

IDBG-644320.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PIAS4

Gene Name

E3 SUMO-protein ligase PIAS4

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000000753

Encoded Proteins

IDBP-696953

E3 SUMO-protein ligase PIAS4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 21199872

[Homo sapiens] PIAS4 is a member of the Protein Inhibitor of Activated STAT protein family, which regulate innate immune response by controlling transcription induced by TLR, RLR and JAK/STAT signalling pathways. PIAS4 specifically negatively regulate both IFN transcription and IFN stimulated gene expression through multiple mechanisms utilizing the function of different domains.

PMID 21199872

[Mus musculus] Pias4 is a member of the Protein Inhibitor of Activated STAT protein family, which regulate innate immune response by controlling transcription induced by Tlr, Rlr and Jak/Stat signalling pathways. Pias4 specifically negatively regulate both Ifn transcription and Ifn stimulated gene expression through multiple mechanisms utilizing the function of different domains.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000105229:

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:21204221-21227471

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000001000

ENSBTAP00000001000

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 78 interaction(s) predicted by orthology.

Predicted by orthology
Total	78 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0019789	SUMO ligase activity
GO:0031625	ubiquitin protein ligase binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0032088	negative regulation of NF-kappaB transcription factor activity
GO:0033235	positive regulation of protein sumoylation
GO:0045892	negative regulation of transcription, DNA-templated
GO:1902174	positive regulation of keratinocyte apoptotic process
GO:1902231	positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage