InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: PRKDC

Summary

InnateDB Protein

IDBP-696969.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PRKDC

Protein Name

protein kinase, DNA-activated, catalytic polypeptide

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000022631

InnateDB Gene

IDBG-644289 (PRKDC)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 202 interaction(s) predicted by orthology.

Predicted by orthology
Total	202 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003677	DNA binding
GO:0004674	protein serine/threonine kinase activity
GO:0004677	DNA-dependent protein kinase activity
GO:0005488	binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008134	transcription factor binding
GO:0016301	kinase activity
GO:0016740	transferase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0016773	phosphotransferase activity, alcohol group as acceptor
GO:0019899	enzyme binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000723	telomere maintenance
GO:0001756	somitogenesis
GO:0001933	negative regulation of protein phosphorylation
GO:0002326	B cell lineage commitment
GO:0002328	pro-B cell differentiation
GO:0002360	T cell lineage commitment
GO:0006302	double-strand break repair
GO:0006303	double-strand break repair via nonhomologous end joining
GO:0007420	brain development
GO:0007507	heart development
GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage
GO:0010332	response to gamma radiation
GO:0016310	phosphorylation
GO:0018105	peptidyl-serine phosphorylation
GO:0030098	lymphocyte differentiation
GO:0031648	protein destabilization
GO:0032869	cellular response to insulin stimulus
GO:0033077	T cell differentiation in thymus
GO:0033152	immunoglobulin V(D)J recombination
GO:0033153	T cell receptor V(D)J recombination
GO:0035234	ectopic germ cell programmed cell death
GO:0042752	regulation of circadian rhythm
GO:0043065	positive regulation of apoptotic process
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0072431	signal transduction involved in mitotic G1 DNA damage checkpoint

Cellular Component

GO:0005634	nucleus
GO:0005667	transcription factor complex
GO:0005958	DNA-dependent protein kinase-DNA ligase 4 complex
GO:0016020	membrane
GO:0070419	nonhomologous end joining complex

Protein Structure and Domains

PDB ID

InterPro

IPR000403 Phosphatidylinositol 3-/4-kinase, catalytic domain
IPR003151 PIK-related kinase, FAT
IPR003152 PIK-related kinase, FATC
IPR011009 Protein kinase-like domain
IPR012582 NUC194
IPR014009 PIK-related kinase
IPR016024 Armadillo-type fold

PFAM

PF00454
PF02259
PF02260
PF08163

PRINTS

PIRSF

SMART

SM00146

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite