InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: LYN

Summary

InnateDB Protein

IDBP-697081.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LYN

Protein Name

v-yes-1 Yamaguchi sarcoma viral related oncogene homolog

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000026686

InnateDB Gene

IDBG-644437 (LYN)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 120 interaction(s) predicted by orthology.

Predicted by orthology
Total	120 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0016740	transferase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0017124	SH3 domain binding
GO:0019899	enzyme binding
GO:0032403	protein complex binding
GO:0044325	ion channel binding

Biological Process

GO:0001782	B cell homeostasis
GO:0001817	regulation of cytokine production
GO:0001933	negative regulation of protein phosphorylation
GO:0002431	Fc receptor mediated stimulatory signaling pathway
GO:0002513	tolerance induction to self antigen
GO:0002576	platelet degranulation
GO:0002762	negative regulation of myeloid leukocyte differentiation
GO:0002768	immune response-regulating cell surface receptor signaling pathway
GO:0002774	Fc receptor mediated inhibitory signaling pathway
GO:0002902	regulation of B cell apoptotic process
GO:0006468	protein phosphorylation
GO:0006974	cellular response to DNA damage stimulus
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
GO:0008284	positive regulation of cell proliferation
GO:0008285	negative regulation of cell proliferation
GO:0009725	response to hormone
GO:0010976	positive regulation of neuron projection development
GO:0016310	phosphorylation
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0030097	hemopoiesis
GO:0030218	erythrocyte differentiation
GO:0030335	positive regulation of cell migration
GO:0030889	negative regulation of B cell proliferation
GO:0031175	neuron projection development
GO:0031663	lipopolysaccharide-mediated signaling pathway
GO:0033003	regulation of mast cell activation
GO:0033628	regulation of cell adhesion mediated by integrin
GO:0034136	negative regulation of toll-like receptor 2 signaling pathway
GO:0034144	negative regulation of toll-like receptor 4 signaling pathway
GO:0035556	intracellular signal transduction
GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein
GO:0043304	regulation of mast cell degranulation
GO:0043407	negative regulation of MAP kinase activity
GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity
GO:0045646	regulation of erythrocyte differentiation
GO:0046777	protein autophosphorylation
GO:0050707	regulation of cytokine secretion
GO:0050727	regulation of inflammatory response
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:0050853	B cell receptor signaling pathway
GO:0050855	regulation of B cell receptor signaling pathway
GO:0050861	positive regulation of B cell receptor signaling pathway
GO:0051272	positive regulation of cellular component movement
GO:0051279	regulation of release of sequestered calcium ion into cytosol
GO:0070304	positive regulation of stress-activated protein kinase signaling cascade
GO:0070372	regulation of ERK1 and ERK2 cascade
GO:0070373	negative regulation of ERK1 and ERK2 cascade
GO:0070667	negative regulation of mast cell proliferation
GO:0070668	positive regulation of mast cell proliferation
GO:0071300	cellular response to retinoic acid
GO:0090025	regulation of monocyte chemotaxis
GO:0090330	regulation of platelet aggregation
GO:0097028	dendritic cell differentiation
GO:1902532	negative regulation of intracellular signal transduction
GO:2000670	positive regulation of dendritic cell apoptotic process

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0045121	membrane raft
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR000980 SH2 domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR001452 SH3 domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR011511 Variant SH3 domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM