InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: AK2

Summary

InnateDB Protein

IDBP-697165.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AK2

Protein Name

adenylate kinase 2, mitochondrial

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000023406

InnateDB Gene

IDBG-644524 (AK2)

Protein Structure

UniProt Annotation

Function

Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis. {ECO:0000255HAMAP- Rule:MF_03168}.

Subcellular Localization

Mitochondrion intermembrane space.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.

Predicted by orthology
Total	23 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0004017	adenylate kinase activity
GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0016740	transferase activity
GO:0016776	phosphotransferase activity, phosphate group as acceptor
GO:0019205	nucleobase-containing compound kinase activity

Biological Process

GO:0006139	nucleobase-containing compound metabolic process
GO:0006172	ADP biosynthetic process
GO:0016310	phosphorylation
GO:0046033	AMP metabolic process
GO:0046034	ATP metabolic process
GO:0046939	nucleotide phosphorylation

Cellular Component

GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0005758	mitochondrial intermembrane space
GO:0036126	sperm flagellum
GO:0070062	extracellular vesicular exosome
GO:0097226	sperm mitochondrial sheath

Protein Structure and Domains

PDB ID

InterPro

IPR000850 Adenylate kinase/UMP-CMP kinase
IPR006259 Adenylate kinase subfamily
IPR007862 Adenylate kinase, active site lid domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF05191

PRINTS

PR00094

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P08166