InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: AK2

Summary

InnateDB Gene

IDBG-644524.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AK2

Gene Name

Adenylate kinase 2, mitochondrial

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000017605

Encoded Proteins

IDBP-697165

adenylate kinase 2, mitochondrial

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000004455:
Adenylate kinases are involved in regulating the adenine nucleotide composition within a cell by catalyzing the reversible transfer of phosphate groups among adenine nucleotides. Three isozymes of adenylate kinase, namely 1, 2, and 3, have been identified in vertebrates; this gene encodes isozyme 2. Expression of these isozymes is tissue-specific and developmentally regulated. Isozyme 2 is localized in the mitochondrial intermembrane space and may play a role in apoptosis. Mutations in this gene are the cause of reticular dysgenesis. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 1 and 2.[provided by RefSeq, Nov 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:121486298-121509903

Strand

Forward strand

Band

Transcripts

ENSBTAT00000023406

ENSBTAP00000023406

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.

Predicted by orthology
Total	23 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0004017	adenylate kinase activity
GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0016740	transferase activity
GO:0016776	phosphotransferase activity, phosphate group as acceptor
GO:0019205	nucleobase-containing compound kinase activity

Biological Process

GO:0006139	nucleobase-containing compound metabolic process
GO:0006172	ADP biosynthetic process
GO:0016310	phosphorylation
GO:0046033	AMP metabolic process
GO:0046034	ATP metabolic process
GO:0046939	nucleotide phosphorylation

Cellular Component

GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0005758	mitochondrial intermembrane space
GO:0036126	sperm flagellum
GO:0070062	extracellular vesicular exosome
GO:0097226	sperm mitochondrial sheath