InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: CRH

Summary

InnateDB Protein

IDBP-697253.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CRH

Protein Name

Corticoliberin

Synonyms

CRF;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000044298

InnateDB Gene

IDBG-644607 (CRH)

Protein Structure

UniProt Annotation

Function

This hormone from hypothalamus regulates the release of corticotropin from pituitary gland. {ECO:0000250}.

Subcellular Localization

Secreted {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005179	hormone activity
GO:0005515	protein binding

Biological Process

GO:0001963	synaptic transmission, dopaminergic
GO:0006704	glucocorticoid biosynthetic process
GO:0006954	inflammatory response
GO:0007565	female pregnancy
GO:0030324	lung development
GO:0030325	adrenal gland development
GO:0035641	locomotory exploration behavior
GO:0051464	positive regulation of cortisol secretion
GO:2000310	regulation of N-methyl-D-aspartate selective glutamate receptor activity

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space

Protein Structure and Domains

PDB ID

InterPro

IPR000187 Corticotropin-releasing factor, CRF
IPR003620 Urocortin/corticotropin-releasing factor

PFAM

PF00473

PRINTS

PR01612

PIRSF

SMART

SM00039

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q95MI6

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

280755

UniGene

Bt.37342

RefSeq

NP_001013418

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

AF340152 BC147872

GenPept

AAI47873 AAK83231