InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: CRH

Summary

InnateDB Gene

IDBG-644607.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CRH

Gene Name

Corticoliberin

Synonyms

CRF

Species

Bos taurus

Ensembl Gene

ENSBTAG00000033128

Encoded Proteins

IDBP-697253

Corticoliberin

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000147571:
Corticotropin-releasing hormone is secreted by the paraventricular nucleus (PVN) of the hypothalamus in response to stress. Marked reduction in this protein has been observed in association with Alzheimer disease and autosomal recessive hypothalamic corticotropin deficiency has multiple and potentially fatal metabolic consequences including hypoglycemia and hepatitis. In addition to production in the hypothalamus, this protein is also synthesized in peripheral tissues, such as T lymphocytes and is highly expressed in the placenta. In the placenta it is a marker that determines the length of gestation and the timing of parturition and delivery. A rapid increase in circulating levels of the hormone occurs at the onset of parturition, suggesting that, in addition to its metabolic functions, this protein may act as a trigger for parturition. [provided by RefSeq, Apr 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 14:32213577-32215193

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000047063

ENSBTAP00000044298

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005179	hormone activity
GO:0005515	protein binding

Biological Process

GO:0001963	synaptic transmission, dopaminergic
GO:0006704	glucocorticoid biosynthetic process
GO:0006954	inflammatory response
GO:0007565	female pregnancy
GO:0030324	lung development
GO:0030325	adrenal gland development
GO:0035641	locomotory exploration behavior
GO:0051464	positive regulation of cortisol secretion
GO:2000310	regulation of N-methyl-D-aspartate selective glutamate receptor activity