Version 5.4
Bos taurus Protein: CLCF1
Summary
InnateDB Protein IDBP-697340.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CLCF1
Protein Name cardiotrophin-like cytokine factor 1
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000054359
InnateDB Gene IDBG-644688 (CLCF1)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0005125 cytokine activity
GO:0005127 ciliary neurotrophic factor receptor binding
GO:0005515 protein binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0002639 positive regulation of immunoglobulin production
GO:0007166 cell surface receptor signaling pathway
GO:0007259 JAK-STAT cascade
GO:0008284 positive regulation of cell proliferation
GO:0030183 B cell differentiation
GO:0030890 positive regulation of B cell proliferation
GO:0040007 growth
GO:0042517 positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0043524 negative regulation of neuron apoptotic process
GO:0048295 positive regulation of isotype switching to IgE isotypes
GO:0048711 positive regulation of astrocyte differentiation
Cellular Component
GO:0005737 cytoplasm
GO:0070062 extracellular vesicular exosome
GO:0097058 CRLF-CLCF1 complex
GO:0097059 CNTFR-CLCF1 complex
Protein Structure and Domains
PDB ID
InterPro IPR000151 Ciliary neurotrophic factor, CNTF
IPR009079 Four-helical cytokine-like, core
IPR010681 Plethodontid receptivity factor PRF
PFAM PF01110
PF06875
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL G3MXT9
UniProt Splice Variant
Entrez Gene 100336481
UniGene
RefSeq XP_002699410
HUGO HGNC:17412
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02063613 DAAA02063614
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca