InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: CLCF1

Summary

InnateDB Gene

IDBG-644688.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CLCF1

Gene Name

Uncharacterized protein

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000046110

Encoded Proteins

IDBP-697340

cardiotrophin-like cytokine factor 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000175505:
This gene is a member of the glycoprotein (gp)130 cytokine family and encodes cardiotrophin-like cytokine factor 1 (CLCF1). CLCF1 forms a heterodimer complex with cytokine receptor-like factor 1 (CRLF1). This dimer competes with ciliary neurotrophic factor (CNTF) for binding to the ciliary neurotrophic factor receptor (CNTFR) complex, and activates the Jak-STAT signaling cascade. CLCF1 can be actively secreted from cells by forming a complex with soluble type I CRLF1 or soluble CNTFR. CLCF1 is a potent neurotrophic factor, B-cell stimulatory agent and neuroendocrine modulator of pituitary corticotroph function. Defects in CLCF1 cause cold-induced sweating syndrome 2 (CISS2). This syndrome is characterized by a profuse sweating after exposure to cold as well as congenital physical abnormalities of the head and spine. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Oct 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 29:45910397-45912701

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000064317

ENSBTAP00000054359

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005125	cytokine activity
GO:0005127	ciliary neurotrophic factor receptor binding
GO:0005515	protein binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0002639	positive regulation of immunoglobulin production
GO:0007166	cell surface receptor signaling pathway
GO:0007259	JAK-STAT cascade
GO:0008284	positive regulation of cell proliferation
GO:0030183	B cell differentiation
GO:0030890	positive regulation of B cell proliferation
GO:0040007	growth
GO:0042517	positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0043524	negative regulation of neuron apoptotic process
GO:0048295	positive regulation of isotype switching to IgE isotypes
GO:0048711	positive regulation of astrocyte differentiation

Cellular Component

GO:0005737	cytoplasm
GO:0070062	extracellular vesicular exosome
GO:0097058	CRLF-CLCF1 complex
GO:0097059	CNTFR-CLCF1 complex

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000175505

View Gene Order

ENSMUSG00000040663

View Gene Order

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

hsa04060

Cytokine-cytokine receptor interaction pathway

hsa04630

Jak-STAT signaling pathway pathway

mmu04060

Cytokine-cytokine receptor interaction pathway

mmu04630

Jak-STAT signaling pathway pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

RefSeq

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

GenPept

RNA Seq Atlas

Transcript Frequencies

Tag Count based mRNA-Abundances across 87 different Tissues (TPM).

Based on Data from Bovine Gene Atlas

Tag Count based mRNA-Abundances across 87 different Tissues (TPM)

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