InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SMC5

Summary

InnateDB Protein

IDBP-69735.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SMC5

Protein Name

structural maintenance of chromosomes 5

Synonyms

SMC5L1;

Species

Homo sapiens

Ensembl Protein

ENSP00000354957

InnateDB Gene

IDBG-69731 (SMC5)

Protein Structure

UniProt Annotation

Function

Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Required for recruitment of telomeres to PML nuclear bodies. Required for sister chromatid cohesion during prometaphase and mitotic progression; the function seems to be independent of SMC6. {ECO:0000269PubMed:16810316, ECO:0000269PubMed:17589526, ECO:0000269PubMed:19502785}.

Subcellular Localization

Nucleus. Chromosome. Chromosome, telomere. Note=Associates with chromatin. Localizes to PML nuclear bodies in ALT cell lines.

Disease Associations

Tissue Specificity

Widely expressed. {ECO:0000269PubMed:11408570}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.

Experimentally validated
Total	17 [view]
Protein-Protein	17 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005524	ATP binding

Biological Process

GO:0000722	telomere maintenance via recombination
GO:0000724	double-strand break repair via homologous recombination
GO:0007067	mitotic nuclear division
GO:0034184	positive regulation of maintenance of mitotic sister chromatid cohesion
GO:0045842	positive regulation of mitotic metaphase/anaphase transition
GO:0090398	cellular senescence