InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: CSF2

Summary

InnateDB Protein

IDBP-697358.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CSF2

Protein Name

Granulocyte-macrophage colony-stimulating factor

Synonyms

CSF; GM-CSF; GMCSF;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000002054

InnateDB Gene

IDBG-644701 (CSF2)

Protein Structure

UniProt Annotation

Function

Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. {ECO:0000250}.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.

Predicted by orthology
Total	15 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity
GO:0005129	granulocyte macrophage colony-stimulating factor receptor binding
GO:0005515	protein binding
GO:0008083	growth factor activity

Biological Process

GO:0001892	embryonic placenta development
GO:0006955	immune response
GO:0008284	positive regulation of cell proliferation
GO:0010468	regulation of gene expression
GO:0010628	positive regulation of gene expression
GO:0010744	positive regulation of macrophage derived foam cell differentiation
GO:0032747	positive regulation of interleukin-23 production
GO:0042127	regulation of cell proliferation
GO:0042523	positive regulation of tyrosine phosphorylation of Stat5 protein
GO:0043011	myeloid dendritic cell differentiation
GO:0045740	positive regulation of DNA replication
GO:0045918	negative regulation of cytolysis
GO:0071803	positive regulation of podosome assembly
GO:0097028	dendritic cell differentiation
GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space

Protein Structure and Domains

PDB ID

InterPro

IPR000773 Granulocyte-macrophage colony-stimulating factor
IPR009079 Four-helical cytokine-like, core

PFAM

PF01109

PRINTS

PR00693

PIRSF

SMART

SM00040

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P11052

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

281095

UniGene

Bt.509

RefSeq

NP_776452

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

U22385

GenPept

AAA66075