Version 5.4
Bos taurus Gene: CSF2
Summary
InnateDB Gene IDBG-644701.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CSF2
Gene Name Granulocyte-macrophage colony-stimulating factor
Synonyms CSF; GM-CSF; GMCSF
Species Bos taurus
Ensembl Gene ENSBTAG00000001570
Encoded Proteins
IDBP-697358
Granulocyte-macrophage colony-stimulating factor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 23453633
[Mus musculus] CSF2 is a negative regulator of IL21-mediated apoptosis in conventional dendritic cells.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000164400:
The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of granulocytes and macrophages. The active form of the protein is found extracellularly as a homodimer. This gene has been localized to a cluster of related genes at chromosome region 5q31, which is known to be associated with interstitial deletions in the 5q- syndrome and acute myelogenous leukemia. Other genes in the cluster include those encoding interleukins 4, 5, and 13. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:23694183-23696548
Strand Reverse strand
Band
Transcripts
ENSBTAT00000002054 ENSBTAP00000002054
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.
Predicted by orthology
Total 15 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005125 cytokine activity
GO:0005129 granulocyte macrophage colony-stimulating factor receptor binding
GO:0005515 protein binding
GO:0008083 growth factor activity
Biological Process
GO:0001892 embryonic placenta development
GO:0006955 immune response
GO:0008284 positive regulation of cell proliferation
GO:0010468 regulation of gene expression
GO:0010628 positive regulation of gene expression
GO:0010744 positive regulation of macrophage derived foam cell differentiation
GO:0032747 positive regulation of interleukin-23 production
GO:0042127 regulation of cell proliferation
GO:0042523 positive regulation of tyrosine phosphorylation of Stat5 protein
GO:0043011 myeloid dendritic cell differentiation
GO:0045740 positive regulation of DNA replication
GO:0045918 negative regulation of cytolysis
GO:0071803 positive regulation of podosome assembly
GO:0097028 dendritic cell differentiation
GO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000164400
View Gene Order
ENSMUSG00000018916
View Gene Order
Pathways
NETPATH
REACTOME
REACT_205369
Signaling by GPCR pathway
REACT_226349
Interleukin-2 signaling pathway
REACT_213612
Cytokine Signaling in Immune system pathway
REACT_212196
Hemostasis pathway
REACT_213138
Immune System pathway
REACT_223657
Interleukin receptor SHC signaling pathway
REACT_209572
Platelet activation, signaling and aggregation pathway
REACT_214353
Signal Transduction pathway
REACT_219098
GPVI-mediated activation cascade pathway
REACT_214436
GPCR downstream signaling pathway
REACT_203136
G-protein beta:gamma signalling pathway
REACT_211267
Interleukin-3, 5 and GM-CSF signaling pathway
REACT_206833
Signaling by Interleukins pathway
REACT_202218
G beta:gamma signalling through PI3Kgamma pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_23891
Interleukin receptor SHC signaling pathway
REACT_23837
Interleukin-3, 5 and GM-CSF signaling pathway
REACT_27283
Interleukin-2 signaling pathway
REACT_1695
GPVI-mediated activation cascade pathway
REACT_19290
G beta:gamma signalling through PI3Kgamma pathway
REACT_75790
Cytokine Signaling in Immune system pathway
REACT_14797
Signaling by GPCR pathway
REACT_798
Platelet activation, signaling and aggregation pathway
REACT_19388
G-protein beta:gamma signalling pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_6900
Immune System pathway
REACT_22232
Signaling by Interleukins pathway
REACT_604
Hemostasis pathway
REACT_223625
GPCR downstream signaling pathway
REACT_224553
Hemostasis pathway
REACT_254215
Signaling by GPCR pathway
REACT_261365
Interleukin-2 signaling pathway
REACT_233584
Cytokine Signaling in Immune system pathway
REACT_230745
Immune System pathway
REACT_224879
Platelet activation, signaling and aggregation pathway
REACT_220092
GPVI-mediated activation cascade pathway
REACT_210793
Interleukin receptor SHC signaling pathway
REACT_261687
Signaling by Interleukins pathway
REACT_207835
G-protein beta:gamma signalling pathway
REACT_225836
Interleukin-3, 5 and GM-CSF signaling pathway
REACT_188257
Signal Transduction pathway
REACT_223974
G beta:gamma signalling through PI3Kgamma pathway
KEGG
hsa04640
Hematopoietic cell lineage pathway
hsa04664
Fc epsilon RI signaling pathway pathway
hsa04060
Cytokine-cytokine receptor interaction pathway
hsa04660
T cell receptor signaling pathway pathway
hsa04630
Jak-STAT signaling pathway pathway
hsa04650
Natural killer cell mediated cytotoxicity pathway
hsa05146
Amoebiasis pathway
mmu04060
Cytokine-cytokine receptor interaction pathway
mmu04630
Jak-STAT signaling pathway pathway
mmu04640
Hematopoietic cell lineage pathway
mmu04660
T cell receptor signaling pathway pathway
mmu04664
Fc epsilon RI signaling pathway pathway
mmu04650
Natural killer cell mediated cytotoxicity pathway
mmu05146
Amoebiasis pathway
INOH
INOH website
JAK STAT pathway and regulation pathway
INOH website
GPCR signaling pathway
INOH website
JAK STAT pathway and regulation pathway
INOH website
GPCR signaling pathway
PID NCI
syndecan_2_pathway
Syndecan-2-mediated signaling events
tcrcalciumpathway
Calcium signaling in the CD4+ TCR pathway
rb_1pathway
Regulation of retinoblastoma protein
nfat_tfpathway
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
integrin_a9b1_pathway
Alpha9 beta1 integrin signaling events
ap1_pathway
AP-1 transcription factor network
reg_gr_pathway
Glucocorticoid receptor regulatory network
gmcsf_pathway
GMCSF-mediated signaling events
Cross-References
SwissProt P11052
TrEMBL
UniProt Splice Variant
Entrez Gene 281095
UniGene Bt.509
RefSeq NM_174027
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL U22385
GenPept AAA66075
RNA Seq Atlas 281095

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca