InnateDB Protein
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IDBP-69741.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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RHBDF2
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Protein Name
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rhomboid 5 homolog 2 (Drosophila)
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000322775
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InnateDB Gene
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IDBG-69739 (RHBDF2)
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Protein Structure
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Function |
Rhomboid protease-like protein which has no protease activity but regulates the secretion of several ligands of the epidermal growth factor receptor. Indirectly activates the epidermal growth factor receptor signaling pathway and may thereby regulate sleep, cell survival, proliferation and migration (By similarity). {ECO:0000250}.
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Subcellular Localization |
Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell membrane {ECO:0000269PubMed:22265016}.
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Disease Associations |
Tylosis with esophageal cancer (TOC) [MIM:148500]: An autosomal dominant syndrome characterized by diffuse palmoplantar keratoderma, oral leukokeratosis, and a high lifetime risk of esophageal cancer. {ECO:0000269PubMed:22265016}. Note=The disease is caused by mutations affecting the gene represented in this entry.
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Tissue Specificity |
Found in the epidermis and esophageal epithelium. {ECO:0000269PubMed:22265016}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
3 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR022241
Rhomboid serine protease
IPR022764
Peptidase S54, rhomboid domain
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PFAM |
PF12595
PF01694
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q6PJF5
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PhosphoSite |
PhosphoSite-Q6PJF5
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TrEMBL |
K7EQT5
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UniProt Splice Variant |
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Entrez Gene |
79651
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UniGene |
Hs.464157
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RefSeq |
NP_078875
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HUGO |
HGNC:20788
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OMIM |
614404
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CCDS |
CCDS32743
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HPRD |
07987
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IMGT |
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EMBL |
AC015802
AK025994
AK292135
AK292166
AY500247
BC016034
BC035829
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GenPept |
AAH16034
AAH35829
AAS77567
BAB15310
BAF84824
BAF84855
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