Version 5.4
Homo sapiens Gene: RHBDF2
Summary
InnateDB Gene IDBG-69739.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RHBDF2
Gene Name rhomboid 5 homolog 2 (Drosophila)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000129667
Encoded Proteins
IDBP-69741
rhomboid 5 homolog 2 (Drosophila)
IDBP-761305
IDBP-761851
IDBP-761004
IDBP-764036
IDBP-760635
IDBP-762373
IDBP-761509
IDBP-762189
IDBP-760959
IDBP-764761
IDBP-761594
IDBP-761960
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 22550345
RHBDF2 is required for the secretion of TNF in macrophages. (Demonstrated in mice)
InnateDB Annotation from Orthologs
Summary
PMID 22550345
[Mus musculus] Rhbdf2 is required for the secretion of Tnf in macrophages.
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 17:76470891-76501790
Strand Reverse strand
Band q25.1
Transcripts
ENST00000313080 ENSP00000322775
ENST00000593103
ENST00000591879 ENSP00000465531
ENST00000585701 ENSP00000466029
ENST00000592378
ENST00000591860 ENSP00000467468
ENST00000589582
ENST00000587640
ENST00000590322 ENSP00000464975
ENST00000585989 ENSP00000465632
ENST00000591255 ENSP00000465124
ENST00000591697 ENSP00000464942
ENST00000592123 ENSP00000467549
ENST00000590288 ENSP00000465990
ENST00000591885 ENSP00000466867
ENST00000589526 ENSP00000467677
ENST00000591192 ENSP00000467971
ENST00000590168
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004252 serine-type endopeptidase activity
GO:0019838 growth factor binding
Biological Process
GO:0006508 proteolysis
GO:0015031 protein transport
GO:0045087 innate immune response (InnateDB)
GO:0050709 negative regulation of protein secretion
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000020806
View Gene Order
ENSBTAG00000003436
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.464157
RefSeq NM_001005498 NM_024599 XM_005257669 XM_005257670
HUGO
OMIM
CCDS CCDS32743 CCDS32744
HPRD 07987
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca