InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: GSTP1

Summary

InnateDB Protein

IDBP-697458.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GSTP1

Protein Name

Glutathione S-transferase P

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000004615

InnateDB Gene

IDBG-644794 (GSTP1)

Protein Structure

UniProt Annotation

Function

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Mitochondrion {ECO:0000250}. Nucleus {ECO:0000250}. Note=The 83 N-terminal amino acids function as un uncleaved transit peptide, and arginine residues within it are crucial for mitochondrial localization. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 25 interaction(s) predicted by orthology.

Predicted by orthology
Total	25 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004364	glutathione transferase activity
GO:0005515	protein binding
GO:0016740	transferase activity
GO:0035730	S-nitrosoglutathione binding
GO:0035731	dinitrosyl-iron complex binding

Biological Process

GO:0006469	negative regulation of protein kinase activity
GO:0006749	glutathione metabolic process
GO:0006805	xenobiotic metabolic process
GO:0008152	metabolic process
GO:0009890	negative regulation of biosynthetic process
GO:0032691	negative regulation of interleukin-1 beta production
GO:0032720	negative regulation of tumor necrosis factor production
GO:0043407	negative regulation of MAP kinase activity
GO:0043508	negative regulation of JUN kinase activity
GO:0051771	negative regulation of nitric-oxide synthase biosynthetic process
GO:0070373	negative regulation of ERK1 and ERK2 cascade
GO:0071638	negative regulation of monocyte chemotactic protein-1 production
GO:2001237	negative regulation of extrinsic apoptotic signaling pathway

Cellular Component

GO:0005615	extracellular space
GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005886	plasma membrane
GO:0070062	extracellular vesicular exosome
GO:0097057	TRAF2-GSTP1 complex

Protein Structure and Domains

PDB ID

InterPro

IPR003080 Glutathione S-transferase, alpha class
IPR003082 Glutathione S-transferase, Pi class
IPR004045 Glutathione S-transferase, N-terminal
IPR004046 Glutathione S-transferase, C-terminal
IPR010987 Glutathione S-transferase, C-terminal-like
IPR012336 Thioredoxin-like fold

PFAM