InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: GSTP1

Summary

InnateDB Gene

IDBG-644794.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GSTP1

Gene Name

Glutathione S-transferase P

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000003548

Encoded Proteins

IDBP-697458

Glutathione S-transferase P

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 18962899

[Homo sapiens] GSTP1 suppresses LPS (lipopolysaccharide)-induced excessive production of pro-inflammatory factors by inhibiting LPS-stimulated MAPKs (mitogen-activated protein kinases) as well as NF-kappaB activation.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000084207:
Glutathione S-transferases (GSTs) are a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. Based on their biochemical, immunologic, and structural properties, the soluble GSTs are categorized into 4 main classes: alpha, mu, pi, and theta. This GST family member is a polymorphic gene encoding active, functionally different GSTP1 variant proteins that are thought to function in xenobiotic metabolism and play a role in susceptibility to cancer, and other diseases. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 29:46087142-46090005

Strand

Forward strand

Band

Transcripts

ENSBTAT00000004615

ENSBTAP00000004615

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 25 interaction(s) predicted by orthology.

Predicted by orthology
Total	25 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004364	glutathione transferase activity
GO:0005515	protein binding
GO:0016740	transferase activity
GO:0035730	S-nitrosoglutathione binding
GO:0035731	dinitrosyl-iron complex binding

Biological Process

GO:0006469	negative regulation of protein kinase activity
GO:0006749	glutathione metabolic process
GO:0006805	xenobiotic metabolic process
GO:0008152	metabolic process
GO:0009890	negative regulation of biosynthetic process
GO:0032691	negative regulation of interleukin-1 beta production
GO:0032720	negative regulation of tumor necrosis factor production
GO:0043407	negative regulation of MAP kinase activity
GO:0043508	negative regulation of JUN kinase activity
GO:0051771	negative regulation of nitric-oxide synthase biosynthetic process
GO:0070373	negative regulation of ERK1 and ERK2 cascade
GO:0071638	negative regulation of monocyte chemotactic protein-1 production
GO:2001237	negative regulation of extrinsic apoptotic signaling pathway

Cellular Component

GO:0005615	extracellular space
GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005886	plasma membrane
GO:0070062	extracellular vesicular exosome
GO:0097057	TRAF2-GSTP1 complex