InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: YTHDF2

Summary

InnateDB Protein

IDBP-697532.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

YTHDF2

Protein Name

YTH domain family protein 2

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000020940

InnateDB Gene

IDBG-644860 (YTHDF2)

Protein Structure

UniProt Annotation

Function

Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability. Acts as a regulator of mRNA stability: binding to m6A-containing mRNAs results in the localization of to mRNA decay sites, such as processing bodies (P-bodies), leading to mRNA degradation (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm, P-body {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0044822	poly(A) RNA binding
GO:1990247	N6-methyladenosine-containing RNA binding

Biological Process

GO:0043488

regulation of mRNA stability

Cellular Component

GO:0000932	cytoplasmic mRNA processing body
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR007275 YTH domain

PFAM

PF04146

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q0VCZ3

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

541050

UniGene

Bt.66143

RefSeq

NP_001069721

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC119920

GenPept

AAI19921