Version 5.4
Bos taurus Protein: PHACTR4
Summary
InnateDB Protein IDBP-697556.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PHACTR4
Protein Name phosphatase and actin regulator 4
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000003535
InnateDB Gene IDBG-644882 (PHACTR4)
Protein Structure
UniProt Annotation
Function Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1 by interacting with PPP1CA and preventing phosphorylation of PPP1CA at 'Thr-320'. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to dephosphorylation and subsequent activation of cofilin (COF1 or COF2) and repression of the integrin signaling through the RHO/ROCK pathway (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}. Cell projection, lamellipodium {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0008157 protein phosphatase 1 binding
GO:0071862 protein phosphatase type 1 activator activity
Biological Process
GO:0001755 neural crest cell migration
GO:0001843 neural tube closure
GO:0007266 Rho protein signal transduction
GO:0007275 multicellular organismal development
GO:0007399 nervous system development
GO:0030036 actin cytoskeleton organization
GO:0043085 positive regulation of catalytic activity
GO:0048484 enteric nervous system development
GO:0051726 regulation of cell cycle
GO:0061386 closure of optic fissure
GO:2001045 negative regulation of integrin-mediated signaling pathway
Cellular Component
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0030027 lamellipodium
GO:0042995 cell projection
Protein Structure and Domains
PDB ID
InterPro IPR004018 RPEL repeat
PFAM PF02755
PRINTS
PIRSF
SMART SM00707
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt F1MCY2
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 514644
UniGene Bt.30560
RefSeq NP_001095477
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC149103 DAAA02006337
GenPept AAI49104

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca