InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: PROK2

Summary

InnateDB Protein

IDBP-697645.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PROK2

Protein Name

Prokineticin-2

Synonyms

Bv8;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000025742

InnateDB Gene

IDBG-644973 (PROK2)

Protein Structure

UniProt Annotation

Function

May function as an output molecule from the suprachiasmatic nucleus (SCN) that transmits behavioral circadian rhythm. May also function locally within the SCN to synchronize output. Potently contracts gastrointestinal (GI) smooth muscle (By similarity). {ECO:0000250}.

Subcellular Localization

Secreted {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession

GO Term

Biological Process

GO:0001525	angiogenesis
GO:0006935	chemotaxis
GO:0007218	neuropeptide signaling pathway
GO:0007283	spermatogenesis
GO:0007623	circadian rhythm
GO:0008283	cell proliferation
GO:0043066	negative regulation of apoptotic process
GO:0045987	positive regulation of smooth muscle contraction
GO:0048511	rhythmic process

Cellular Component

GO:0005576

extracellular region

Protein Structure and Domains

PDB ID

InterPro

IPR023569 Prokineticin domain

PFAM

PF06607

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q863H5

PhosphoSite

PhosphoSite-

TrEMBL

F1MMX1

UniProt Splice Variant

Entrez Gene

387602

UniGene

RefSeq

NP_955516

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

AY192557 AY192558 DAAA02054040

GenPept

AAP31906 AAP31907