Bos taurus Gene: PROK2
Summary
InnateDB Gene IDBG-644973.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PROK2
Gene Name Prokineticin-2
Synonyms Bv8
Species Bos taurus
Ensembl Gene ENSBTAG00000019330
Encoded Proteins
Prokineticin-2
Prokineticin-2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000163421:
This gene encodes a protein expressed in the suprachiasmatic nucleus (SCN) circadian clock that may function as the output component of the circadian clock. The secreted form of the encoded protein may also serve as a chemoattractant for neuronal precursor cells in the olfactory bulb. Proteins from other vertebrates which are similar to this gene product were isolated based on homology to snake venom and secretions from frog skin, and have been shown to have diverse functions. Mutations in this gene are associated with Kallmann syndrome 4. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:30035342-30044548
Strand Forward strand
Band
Transcripts
ENSBTAT00000025742 ENSBTAP00000025742
ENSBTAT00000025743 ENSBTAP00000025743
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0001525 angiogenesis
GO:0006935 chemotaxis
GO:0007218 neuropeptide signaling pathway
GO:0007283 spermatogenesis
GO:0007623 circadian rhythm
GO:0008283 cell proliferation
GO:0043066 negative regulation of apoptotic process
GO:0045987 positive regulation of smooth muscle contraction
GO:0048511 rhythmic process
Cellular Component
GO:0005576 extracellular region
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
Pathways
NETPATH
REACTOME
Gastrin-CREB signalling pathway via PKC and MAPK pathway
Peptide ligand-binding receptors pathway
Signaling by GPCR pathway
Signal Transduction pathway
G alpha (q) signalling events pathway
GPCR downstream signaling pathway
GPCR ligand binding pathway
Class A/1 (Rhodopsin-like receptors) pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
G alpha (q) signalling events pathway
Gastrin-CREB signalling pathway via PKC and MAPK pathway
Peptide ligand-binding receptors pathway
Class A/1 (Rhodopsin-like receptors) pathway
Signaling by GPCR pathway
Signal Transduction pathway
GPCR downstream signaling pathway
GPCR ligand binding pathway
GPCR downstream signaling pathway
Signaling by GPCR pathway
Class A/1 (Rhodopsin-like receptors) pathway
Gastrin-CREB signalling pathway via PKC and MAPK pathway
GPCR ligand binding pathway
Peptide ligand-binding receptors pathway
G alpha (q) signalling events pathway
Signal Transduction pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL F1MMX0
UniProt Splice Variant
Entrez Gene 387602
UniGene
RefSeq NM_199445
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02054040
GenPept
RNA Seq Atlas 387602