Version 5.4
Bos taurus Protein: ARL6IP5
Summary
InnateDB Protein IDBP-697697.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ARL6IP5
Protein Name PRA1 family protein 3
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000028661
InnateDB Gene IDBG-645018 (ARL6IP5)
Protein Structure
UniProt Annotation
Function Regulates intracellular concentrations of taurine and glutamate. Negatively modulates SLC1A1/EAAC1 glutamate transport activity by decreasing its affinity for glutamate. May be involved in membrane traffic (By similarity). {ECO:0000250}.
Subcellular Localization Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Also exists as a soluble form in the cytoplasm. Associated with microtubules (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Predicted by orthology
Total 13 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress
GO:0010917 negative regulation of mitochondrial membrane potential
GO:0015813 L-glutamate transport
GO:0032874 positive regulation of stress-activated MAPK cascade
GO:0043065 positive regulation of apoptotic process
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
Cellular Component
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR004895 Prenylated rab acceptor PRA1
PFAM PF03208
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q5E9M1
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 509977
UniGene Bt.67496
RefSeq NP_001014891
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC102757 BT020899
GenPept AAI02758 AAX08916

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca