Version 5.4
Bos taurus Gene: ARL6IP5
Summary
InnateDB Gene IDBG-645018.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ARL6IP5
Gene Name PRA1 family protein 3
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000021506
Encoded Proteins
IDBP-697697
PRA1 family protein 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000144746:
Expression of this gene is affected by vitamin A. The encoded protein of this gene may be associated with the cytoskeleton. A similar protein in rats may play a role in the regulation of cell differentiation. The rat protein binds and inhibits the cell membrane glutamate transporter EAAC1. The expression of the rat gene is upregulated by retinoic acid, which results in a specific reduction in EAAC1-mediated glutamate transport. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:32552971-32574431
Strand Reverse strand
Band
Transcripts
ENSBTAT00000028661 ENSBTAP00000028661
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Predicted by orthology
Total 13 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress
GO:0010917 negative regulation of mitochondrial membrane potential
GO:0015813 L-glutamate transport
GO:0032874 positive regulation of stress-activated MAPK cascade
GO:0043065 positive regulation of apoptotic process
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
Cellular Component
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000144746
View Gene Order
ENSMUSG00000035199
View Gene Order
Cross-References
SwissProt Q5E9M1
TrEMBL
UniProt Splice Variant
Entrez Gene 509977
UniGene Bt.13574 Bt.67496
RefSeq NM_001014891
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC102757 BT020899
GenPept AAI02758 AAX08916
RNA Seq Atlas 509977

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca