Version 5.4
Bos taurus Protein: WASF2
Summary
InnateDB Protein IDBP-697704.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol WASF2
Protein Name Wiskott-Aldrich syndrome protein family member 2
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000024447
InnateDB Gene IDBG-645020 (WASF2)
Protein Structure
UniProt Annotation
Function Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm, cytoskeleton {ECO:0000250}. Cell projection, lamellipodium {ECO:0000250}. Note=At the interface between the lamellipodial actin meshwork and the membrane. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.
Predicted by orthology
Total 19 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005515 protein binding
GO:0032403 protein complex binding
Biological Process
GO:0001525 angiogenesis
GO:0001667 ameboidal cell migration
GO:0006897 endocytosis
GO:0006928 cellular component movement
GO:0010592 positive regulation of lamellipodium assembly
GO:0016601 Rac protein signal transduction
GO:0030032 lamellipodium assembly
GO:0030036 actin cytoskeleton organization
GO:0030048 actin filament-based movement
GO:0035855 megakaryocyte development
GO:0051497 negative regulation of stress fiber assembly
GO:0072673 lamellipodium morphogenesis
Cellular Component
GO:0001726 ruffle
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0005769 early endosome
GO:0005856 cytoskeleton
GO:0005911 cell-cell junction
GO:0030027 lamellipodium
GO:0031209 SCAR complex
GO:0042995 cell projection
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR003124 WH2 domain
PFAM PF02205
PRINTS
PIRSF
SMART SM00246
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt A2VDK6
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 504482
UniGene Bt.38300
RefSeq NP_001074980
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC133284
GenPept AAI33285

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca