Version 5.4
Bos taurus Protein: FADD
Summary
InnateDB Protein IDBP-697733.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FADD
Protein Name Protein FADD
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000024322
InnateDB Gene IDBG-645056 (FADD)
Protein Structure
UniProt Annotation
Function Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis (By similarity). Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling (By similarity). {ECO:0000250}.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 88 interaction(s) predicted by orthology.
Predicted by orthology
Total 88 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0002020 protease binding
GO:0005515 protein binding
GO:0032813 tumor necrosis factor receptor superfamily binding
GO:0035877 death effector domain binding
GO:0042802 identical protein binding
Biological Process
GO:0001916 positive regulation of T cell mediated cytotoxicity
GO:0002376 immune system process
GO:0002821 positive regulation of adaptive immune response
GO:0006915 apoptotic process
GO:0007165 signal transduction
GO:0032729 positive regulation of interferon-gamma production
GO:0032757 positive regulation of interleukin-8 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0033077 T cell differentiation in thymus
GO:0036462 TRAIL-activated apoptotic signaling pathway
GO:0042104 positive regulation of activated T cell proliferation
GO:0042981 regulation of apoptotic process
GO:0043029 T cell homeostasis
GO:0043065 positive regulation of apoptotic process
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045087 innate immune response
GO:0045651 positive regulation of macrophage differentiation
GO:0045862 positive regulation of proteolysis
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048535 lymph node development
GO:0048536 spleen development
GO:0048538 thymus development
GO:0051607 defense response to virus
GO:0060340 positive regulation of type I interferon-mediated signaling pathway
GO:0060546 negative regulation of necroptotic process
GO:0070236 negative regulation of activation-induced cell death of T cells
GO:0071260 cellular response to mechanical stimulus
GO:0097049 motor neuron apoptotic process
GO:0097190 apoptotic signaling pathway
GO:0097191 extrinsic apoptotic signaling pathway
GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand
GO:0097202 activation of cysteine-type endopeptidase activity
GO:0097527 necroptotic signaling pathway
GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:2000454 positive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation
GO:2001238 positive regulation of extrinsic apoptotic signaling pathway
Cellular Component
GO:0005829 cytosol
GO:0031264 death-inducing signaling complex
GO:0031265 CD95 death-inducing signaling complex
GO:0097342 ripoptosome
Protein Structure and Domains
PDB ID
InterPro IPR000488 Death domain
IPR001875 Death effector domain
IPR011029 Death-like domain
IPR016729 FADD
PFAM PF00531
PF01335
PRINTS
PIRSF PIRSF018586
SMART SM00005
SM00031
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q645M6
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 493720
UniGene Bt.88785
RefSeq NP_001007817
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AY725483 BC120180
GenPept AAI20181 AAU20801

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca