Version 5.4
Bos taurus Protein: CPLX2
Summary
InnateDB Protein IDBP-697746.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CPLX2
Protein Name Complexin-2
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000018256
InnateDB Gene IDBG-645067 (CPLX2)
Protein Structure
UniProt Annotation
Function Negatively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. Positively regulates a late step in synaptic vesicle exocytosis. Also involved in mast cell exocytosis. {ECO:0000269PubMed:11929859, ECO:0000269PubMed:12200427}.
Subcellular Localization Cytoplasm, cytosol. Note=Enriched at synaptic-releasing sites in mature neurons. {ECO:0000250}.
Disease Associations
Tissue Specificity Nervous system. Also present in adrenal chromaffin cells (at protein level). {ECO:0000269PubMed:11929859}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0019905 syntaxin binding
Biological Process
GO:0006810 transport
GO:0006836 neurotransmitter transport
GO:0006887 exocytosis
GO:0031915 positive regulation of synaptic plasticity
GO:0043303 mast cell degranulation
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0042629 mast cell granule
Protein Structure and Domains
PDB ID
InterPro IPR008849 Synaphin
PFAM PF05835
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P84088
PhosphoSite PhosphoSite-P84088
TrEMBL
UniProt Splice Variant
Entrez Gene 281711
UniGene Bt.87768
RefSeq NP_776708
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL D50807
GenPept BAA09434

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca