Version 5.4
Bos taurus Protein: FAF2
Summary
InnateDB Protein IDBP-697784.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FAF2
Protein Name FAS-associated factor 2
Synonyms UBX8; UBXD8;
Species Bos taurus
Ensembl Protein ENSBTAP00000052507
InnateDB Gene IDBG-645098 (FAF2)
Protein Structure
UniProt Annotation
Function May play a role in the translocation of terminally misfolded proteins from the endoplasmic reticulum lumen to the cytoplasm and their degradation by the proteasome. {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}. Lipid droplet {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 66 interaction(s) predicted by orthology.
Predicted by orthology
Total 66 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0031625 ubiquitin protein ligase binding
GO:0035473 lipase binding
GO:0043130 ubiquitin binding
GO:0055102 lipase inhibitor activity
Biological Process
GO:0006986 response to unfolded protein
GO:0034389 lipid particle organization
GO:0043086 negative regulation of catalytic activity
Cellular Component
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005811 lipid particle
GO:0034098 Cdc48p-Npl4p-Ufd1p AAA ATPase complex
GO:0043231 intracellular membrane-bounded organelle
Protein Structure and Domains
PDB ID
InterPro IPR001012 UBX domain
IPR006577 UAS
IPR009060 UBA-like
IPR029071 Ubiquitin-related domain
PFAM PF00789
PRINTS
PIRSF
SMART SM00166
SM00594
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q2HJD0
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 767948
UniGene Bt.26767
RefSeq NP_001070488
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC105572
GenPept AAI05573

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca