Version 5.4
Bos taurus Protein: INS
Summary
InnateDB Protein IDBP-697932.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol INS
Protein Name insulin precursor
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000017289
InnateDB Gene IDBG-645238 (INS)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0002020 protease binding
GO:0005158 insulin receptor binding
GO:0005159 insulin-like growth factor receptor binding
GO:0005179 hormone activity
GO:0005515 protein binding
GO:0042802 identical protein binding
Biological Process
GO:0000165 MAPK cascade
GO:0002674 negative regulation of acute inflammatory response
GO:0005975 carbohydrate metabolic process
GO:0006006 glucose metabolic process
GO:0006521 regulation of cellular amino acid metabolic process
GO:0006953 acute-phase response
GO:0007186 G-protein coupled receptor signaling pathway
GO:0008284 positive regulation of cell proliferation
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0015758 glucose transport
GO:0022898 regulation of transmembrane transporter activity
GO:0032148 activation of protein kinase B activity
GO:0032270 positive regulation of cellular protein metabolic process
GO:0032460 negative regulation of protein oligomerization
GO:0032880 regulation of protein localization
GO:0033861 negative regulation of NAD(P)H oxidase activity
GO:0042060 wound healing
GO:0042177 negative regulation of protein catabolic process
GO:0042593 glucose homeostasis
GO:0043410 positive regulation of MAPK cascade
GO:0045725 positive regulation of glycogen biosynthetic process
GO:0045740 positive regulation of DNA replication
GO:0045818 negative regulation of glycogen catabolic process
GO:0045821 positive regulation of glycolytic process
GO:0045840 positive regulation of mitosis
GO:0045861 negative regulation of proteolysis
GO:0045922 negative regulation of fatty acid metabolic process
GO:0046326 positive regulation of glucose import
GO:0046628 positive regulation of insulin receptor signaling pathway
GO:0046631 alpha-beta T cell activation
GO:0050708 regulation of protein secretion
GO:0050709 negative regulation of protein secretion
GO:0050715 positive regulation of cytokine secretion
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051897 positive regulation of protein kinase B signaling
GO:0055089 fatty acid homeostasis
GO:0060266 negative regulation of respiratory burst involved in inflammatory response
GO:0060267 positive regulation of respiratory burst
GO:2000252 negative regulation of feeding behavior
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
Protein Structure and Domains
PDB ID
InterPro IPR004825 Insulin
IPR016179 Insulin-like
IPR022352 Insulin family
PFAM PF00049
PRINTS PR00277
PR00276
PIRSF
SMART SM00078
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL I7CLV3
UniProt Splice Variant
Entrez Gene 280829
UniGene
RefSeq NP_776351
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC142034 DAAA02063736 EU518675 JX041514
GenPept AAI42035 ACD35246 AFO70114

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca