InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: BT.89433

Summary

InnateDB Protein

IDBP-697952.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.89433

Protein Name

coagulation factor XII precursor

Synonyms

HAF;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000025122

InnateDB Gene

IDBG-645256 (BT.89433)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004252	serine-type endopeptidase activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0008233	peptidase activity
GO:0008236	serine-type peptidase activity
GO:0016787	hydrolase activity

Biological Process

GO:0002353	plasma kallikrein-kinin cascade
GO:0002542	Factor XII activation
GO:0006508	proteolysis
GO:0007596	blood coagulation
GO:0010756	positive regulation of plasminogen activation
GO:0016485	protein processing
GO:0016540	protein autoprocessing
GO:0030193	regulation of blood coagulation
GO:0030194	positive regulation of blood coagulation
GO:0031638	zymogen activation
GO:0051788	response to misfolded protein
GO:0051919	positive regulation of fibrinolysis

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000001 Kringle
IPR000083 Fibronectin, type I
IPR000562 Fibronectin, type II, collagen-binding
IPR000742 Epidermal growth factor-like domain
IPR001254 Peptidase S1
IPR001314 Peptidase S1A, chymotrypsin-type
IPR001881 EGF-like calcium-binding domain
IPR009003 Trypsin-like cysteine/serine peptidase domain
IPR013806 Kringle-like fold
IPR014394 Coagulation factor XIIa/hepatocyte growth factor activator

PFAM

PF00051
PF00039
PF00040
PF00008
PF00089
PF07645

PRINTS

PR00722

PIRSF

PIRSF001146

SMART

SM00130
SM00058
SM00059
SM00181
SM00020
SM00179

TIGRFAMs

Post-translational Modifications

Modification

Cross-References