InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BT.89433

Summary

InnateDB Gene

IDBG-645256.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.89433

Gene Name

coagulation factor XII precursor

Synonyms

HAF

Species

Bos taurus

Ensembl Gene

ENSBTAG00000018872

Encoded Proteins

IDBP-697952

coagulation factor XII precursor

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000131187:
This gene encodes coagulation factor XII which circulates in blood as a zymogen. This single chain zymogen is converted to a two-chain serine protease with an heavy chain (alpha-factor XIIa) and a light chain. The heavy chain contains two fibronectin-type domains, two epidermal growth factor (EGF)-like domains, a kringle domain and a proline-rich domain, whereas the light chain contains only a catalytic domain. On activation, further cleavages takes place in the heavy chain, resulting in the production of beta-factor XIIa light chain and the alpha-factor XIIa light chain becomes beta-factor XIIa heavy chain. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then to beta-factor XIIa. The active factor XIIa participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. It activates coagulation factors VII and XI. Defects in this gene do not cause any clinical symptoms and the sole effect is that whole-blood clotting time is prolonged. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:40258129-40266423

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000025122

ENSBTAP00000025122

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004252	serine-type endopeptidase activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0008233	peptidase activity
GO:0008236	serine-type peptidase activity
GO:0016787	hydrolase activity

Biological Process

GO:0002353	plasma kallikrein-kinin cascade
GO:0002542	Factor XII activation
GO:0006508	proteolysis
GO:0007596	blood coagulation
GO:0010756	positive regulation of plasminogen activation
GO:0016485	protein processing
GO:0016540	protein autoprocessing
GO:0030193	regulation of blood coagulation
GO:0030194	positive regulation of blood coagulation
GO:0031638	zymogen activation
GO:0051788	response to misfolded protein
GO:0051919	positive regulation of fibrinolysis