InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: PDP1

Summary

InnateDB Protein

IDBP-697982.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PDP1

Protein Name

Synonyms

PDP; PPM2C;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000000233

InnateDB Gene

IDBG-645282 (PDP1)

Protein Structure

UniProt Annotation

Function

Catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex.

Subcellular Localization

Mitochondrion matrix.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0003824	catalytic activity
GO:0004721	phosphoprotein phosphatase activity
GO:0004722	protein serine/threonine phosphatase activity
GO:0004741	[pyruvate dehydrogenase (lipoamide)] phosphatase activity
GO:0005509	calcium ion binding
GO:0016787	hydrolase activity
GO:0046872	metal ion binding

Biological Process

GO:0006470	protein dephosphorylation
GO:0016311	dephosphorylation

Cellular Component

GO:0005739	mitochondrion
GO:0005759	mitochondrial matrix

Protein Structure and Domains

PDB ID

InterPro

IPR001932 Protein phosphatase 2C (PP2C)-like domain

PFAM

PF00481
PF07228

PRINTS

PIRSF

SMART

SM00331
SM00332

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P35816

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

280891

UniGene

Bt.3889

RefSeq

XP_005215707

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

L18966

GenPept

AAA30697