InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: PDE12

Summary

InnateDB Protein

IDBP-697989.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PDE12

Protein Name

2',5'-phosphodiesterase 12

Synonyms

2\'-PDE;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000020675

InnateDB Gene

IDBG-645289 (PDE12)

Protein Structure

UniProt Annotation

Function

Enzyme that cleaves 2',5'-phosphodiester bond linking adenosines of the 5'-triphosphorylated oligoadenylates, triphosphorylated oligoadenylates referred as 2-5A modulates the 2-5A system. This enzyme degraded triphosphorylated 2-5A to produce AMP and ATP. Also cleaves 3',5'-phosphodiester bond of oligoadenylates. Plays a role as a negative regulator of the The 2-5A system that is one of the major pathways for antiviral and antitumor functions induced by interferons (IFNs) (By similarity). {ECO:0000250}.

Subcellular Localization

Mitochondrion matrix {ECO:0000250}.

Disease Associations

Tissue Specificity

Liver. {ECO:0000269PubMed:15231837}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004518	nuclease activity
GO:0004527	exonuclease activity
GO:0004535	poly(A)-specific ribonuclease activity
GO:0016787	hydrolase activity
GO:0046872	metal ion binding

Biological Process

GO:0006397	mRNA processing
GO:0090305	nucleic acid phosphodiester bond hydrolysis
GO:0090503	RNA phosphodiester bond hydrolysis, exonucleolytic

Cellular Component

GO:0005739	mitochondrion
GO:0005759	mitochondrial matrix

Protein Structure and Domains

PDB ID

InterPro

IPR005135 Endonuclease/exonuclease/phosphatase

PFAM

PF03372
PF14529

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q08DF7

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

538860

UniGene

Bt.42120

RefSeq

NP_001069601

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC123772

GenPept

AAI23773