Version 5.4
Bos taurus Gene: PDE12
Summary
InnateDB Gene IDBG-645289.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PDE12
Gene Name 2',5'-phosphodiesterase 12
Synonyms 2\'-PDE
Species Bos taurus
Ensembl Gene ENSBTAG00000015563
Encoded Proteins
IDBP-697989
2',5'-phosphodiesterase 12
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 26055709
[Homo sapiens] PDE12 negatively regulates the innate immune response and inhibitors of PDE12 show increased IFN induced 2â??,5â??- oligoadenylate and antiviral activities.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000174840:
Gene Information
Type Protein coding
Genomic Location Chromosome 22:44179970-44183679
Strand Reverse strand
Band
Transcripts
ENSBTAT00000020675 ENSBTAP00000020675
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004518 nuclease activity
GO:0004527 exonuclease activity
GO:0004535 poly(A)-specific ribonuclease activity
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0006397 mRNA processing
GO:0090305 nucleic acid phosphodiester bond hydrolysis
GO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic
Cellular Component
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000174840
View Gene Order
ENSMUSG00000043702
View Gene Order
Cross-References
SwissProt Q08DF7
TrEMBL
UniProt Splice Variant
Entrez Gene 538860
UniGene Bt.42120
RefSeq NM_001076133
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC123772
GenPept AAI23773
RNA Seq Atlas 538860

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca