Version 5.4
Bos taurus Protein: GNB2L1
Summary
InnateDB Protein IDBP-698088.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GNB2L1
Protein Name Guanine nucleotide-binding protein subunit beta-2-like 1
Synonyms RACK1;
Species Bos taurus
Ensembl Protein ENSBTAP00000026183
InnateDB Gene IDBG-645383 (GNB2L1)
Protein Structure
UniProt Annotation
Function Involved in the recruitment, assembly and/or regulation of a variety of signaling molecules. Interacts with a wide variety of proteins and plays a role in many cellular processes. Component of the 40S ribosomal subunit involved in translational repression. Binds to and stabilizes activated protein kinase C (PKC), increasing PKC-mediated phosphorylation. May recruit activated PKC to the ribosome, leading to phosphorylation of EIF6. Inhibits the activity of SRC kinases including SRC, LCK and YES1. Inhibits cell growth by prolonging the G0/G1 phase of the cell cycle. Enhances phosphorylation of BMAL1 by PRKCA and inhibits transcriptional activity of the BMAL1-CLOCK heterodimer. Facilitates ligand- independent nuclear translocation of AR following PKC activation, represses AR transactivation activity and is required for phosphorylation of AR by SRC. Modulates IGF1R-dependent integrin signaling and promotes cell spreading and contact with the extracellular matrix. Involved in PKC-dependent translocation of ADAM12 to the cell membrane. Promotes the ubiquitination and proteasome-mediated degradation of proteins such as CLEC1B and HIF1A. Required for VANGL2 membrane localization, inhibits Wnt signaling, and regulates cellular polarization and oriented cell division during gastrulation. Required for PTK2/FAK1 phosphorylation and dephosphorylation. Regulates internalization of the muscarinic receptor CHRM2. Promotes apoptosis by increasing oligomerization of BAX and disrupting the interaction of BAX with the anti-apoptotic factor BCL2L. Inhibits TRPM6 channel activity. Regulates cell surface expression of some GPCRs such as TBXA2R. Plays a role in regulation of FLT1-mediated cell migration (By similarity). {ECO:0000250}.
Subcellular Localization Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cytoplasm {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Nucleus {ECO:0000250}. Perikaryon {ECO:0000250}. Cell projection, dendrite {ECO:0000250}. Note=Recruited to the plasma membrane through interaction with KRT1 which binds to membrane-bound ITGB1. PKC activation induces translocation from the perinuclear region to the cell periphery. In the brain, detected mainly in cell bodies and dendrites with little expression in axonal fibers or nuclei (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed in aortic endothelial cells (EC) and the endothelium of tumor neovascularizations. Differential gene expression is displayed in the corpora lutea of the early, mid, and late stages of the ovarian cycle that are associated with progressive, active, and regressive stages of angiogenesis. {ECO:0000269PubMed:11099474}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 125 interaction(s) predicted by orthology.
Predicted by orthology
Total 125 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005080 protein kinase C binding
GO:0005515 protein binding
GO:0008200 ion channel inhibitor activity
GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process
GO:0019899 enzyme binding
GO:0019903 protein phosphatase binding
GO:0030292 protein tyrosine kinase inhibitor activity
GO:0030971 receptor tyrosine kinase binding
GO:0042169 SH2 domain binding
GO:0042803 protein homodimerization activity
GO:0044822 poly(A) RNA binding
Biological Process
GO:0001934 positive regulation of protein phosphorylation
GO:0006417 regulation of translation
GO:0006915 apoptotic process
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007049 cell cycle
GO:0007275 multicellular organismal development
GO:0007369 gastrulation
GO:0010629 negative regulation of gene expression
GO:0030178 negative regulation of Wnt signaling pathway
GO:0030308 negative regulation of cell growth
GO:0030335 positive regulation of cell migration
GO:0030822 positive regulation of cAMP catabolic process
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032464 positive regulation of protein homooligomerization
GO:0032880 regulation of protein localization
GO:0040008 regulation of growth
GO:0043065 positive regulation of apoptotic process
GO:0043524 negative regulation of neuron apoptotic process
GO:0043547 positive regulation of GTPase activity
GO:0048511 rhythmic process
GO:0050765 negative regulation of phagocytosis
GO:0051302 regulation of cell division
GO:0051343 positive regulation of cyclic-nucleotide phosphodiesterase activity
GO:0051726 regulation of cell cycle
GO:0051898 negative regulation of protein kinase B signaling
GO:0051901 positive regulation of mitochondrial depolarization
GO:0061099 negative regulation of protein tyrosine kinase activity
GO:1901299 negative regulation of hydrogen peroxide-mediated programmed cell death
GO:2000114 regulation of establishment of cell polarity
GO:2000543 positive regulation of gastrulation
GO:2001244 positive regulation of intrinsic apoptotic signaling pathway
Cellular Component
GO:0001891 phagocytic cup
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0030425 dendrite
GO:0030496 midbody
GO:0042995 cell projection
GO:0043025 neuronal cell body
GO:0043204 perikaryon
GO:0048471 perinuclear region of cytoplasm
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR001680 WD40 repeat
IPR017986 WD40-repeat-containing domain
IPR020472 G-protein beta WD-40 repeat
PFAM PF00400
PRINTS PR00320
PIRSF
SMART SM00320
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P63243
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 327682
UniGene
RefSeq XP_005199090
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AJ132860 BC102286
GenPept AAI02287 CAB64792

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

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Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca