InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: GNB2L1

Summary

InnateDB Gene

IDBG-645383.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GNB2L1

Gene Name

Guanine nucleotide-binding protein subunit beta-2-like 1

Synonyms

RACK1

Species

Bos taurus

Ensembl Gene

ENSBTAG00000019648

Encoded Proteins

IDBP-698088

Guanine nucleotide-binding protein subunit beta-2-like 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 24323043

[Homo sapiens] GNB2L1 (RACK1) negatively regulates NFκB activation by interacting with CHUK and IKBKB. The interaction interferes with the recruitment of the IKK complex to TRAF2 .

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000204628:

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:41761805-41766598

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000026183

ENSBTAP00000026183

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 125 interaction(s) predicted by orthology.

Predicted by orthology
Total	125 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005080	protein kinase C binding
GO:0005515	protein binding
GO:0008200	ion channel inhibitor activity
GO:0008656	cysteine-type endopeptidase activator activity involved in apoptotic process
GO:0019899	enzyme binding
GO:0019903	protein phosphatase binding
GO:0030292	protein tyrosine kinase inhibitor activity
GO:0030971	receptor tyrosine kinase binding
GO:0042169	SH2 domain binding
GO:0042803	protein homodimerization activity
GO:0044822	poly(A) RNA binding

Biological Process

GO:0001934	positive regulation of protein phosphorylation
GO:0006417	regulation of translation
GO:0006915	apoptotic process
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007049	cell cycle
GO:0007275	multicellular organismal development
GO:0007369	gastrulation
GO:0010629	negative regulation of gene expression
GO:0030178	negative regulation of Wnt signaling pathway
GO:0030308	negative regulation of cell growth
GO:0030335	positive regulation of cell migration
GO:0030822	positive regulation of cAMP catabolic process
GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032464	positive regulation of protein homooligomerization
GO:0032880	regulation of protein localization
GO:0040008	regulation of growth
GO:0043065	positive regulation of apoptotic process
GO:0043524	negative regulation of neuron apoptotic process
GO:0043547	positive regulation of GTPase activity
GO:0048511	rhythmic process
GO:0050765	negative regulation of phagocytosis
GO:0051302	regulation of cell division
GO:0051343	positive regulation of cyclic-nucleotide phosphodiesterase activity
GO:0051726	regulation of cell cycle
GO:0051898	negative regulation of protein kinase B signaling
GO:0051901	positive regulation of mitochondrial depolarization
GO:0061099	negative regulation of protein tyrosine kinase activity
GO:1901299	negative regulation of hydrogen peroxide-mediated programmed cell death
GO:2000114	regulation of establishment of cell polarity
GO:2000543	positive regulation of gastrulation
GO:2001244	positive regulation of intrinsic apoptotic signaling pathway

Cellular Component

GO:0001891	phagocytic cup
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005829	cytosol
GO:0005856	cytoskeleton
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0030425	dendrite
GO:0030496	midbody
GO:0042995	cell projection
GO:0043025	neuronal cell body
GO:0043204	perikaryon
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome