Version 5.4
Bos taurus Protein: HMGCL
Summary
InnateDB Protein IDBP-698106.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HMGCL
Protein Name Hydroxymethylglutaryl-CoA lyase, mitochondrial
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000029103
InnateDB Gene IDBG-645400 (HMGCL)
Protein Structure
UniProt Annotation
Function Key enzyme in ketogenesis (ketone body formation). Terminal step in leucine catabolism. Ketone bodies (beta- hydroxybutyrate, acetoacetate and acetone) are essential as an alternative source of energy to glucose, as lipid precursors and as regulators of metabolism (By similarity). {ECO:0000250}.
Subcellular Localization Mitochondrion matrix {ECO:0000250}. Peroxisome {ECO:0000250}. Note=Unprocessed form is peroxisomal. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000287 magnesium ion binding
GO:0003824 catalytic activity
GO:0004419 hydroxymethylglutaryl-CoA lyase activity
GO:0005102 receptor binding
GO:0016829 lyase activity
GO:0030145 manganese ion binding
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
Biological Process
GO:0007005 mitochondrion organization
GO:0046951 ketone body biosynthetic process
GO:0051262 protein tetramerization
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005759 mitochondrial matrix
GO:0005777 peroxisome
Protein Structure and Domains
PDB ID
InterPro IPR000891 Pyruvate carboxyltransferase
PFAM PF00682
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q29448
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 317658
UniGene Bt.9446
RefSeq NP_001068600
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC118276 U41409
GenPept AAA86757 AAI18277

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca