InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: HMGCL

Summary

InnateDB Gene

IDBG-645400.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HMGCL

Gene Name

Hydroxymethylglutaryl-CoA lyase, mitochondrial

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000021832

Encoded Proteins

IDBP-698106

Hydroxymethylglutaryl-CoA lyase, mitochondrial

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000117305:
The protein encoded by this gene belongs to the HMG-CoA lyase family. It is a mitochondrial enzyme that catalyzes the final step of leucine degradation and plays a key role in ketone body formation. Mutations in this gene are associated with HMG-CoA lyase deficiency. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:129687547-129705679

Strand

Forward strand

Band

Transcripts

ENSBTAT00000029103

ENSBTAP00000029103

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0003824	catalytic activity
GO:0004419	hydroxymethylglutaryl-CoA lyase activity
GO:0005102	receptor binding
GO:0016829	lyase activity
GO:0030145	manganese ion binding
GO:0042803	protein homodimerization activity
GO:0046872	metal ion binding