InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: PRKCD

Summary

InnateDB Protein

IDBP-698155.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PRKCD

Protein Name

protein kinase C delta type

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000011487

InnateDB Gene

IDBG-645450 (PRKCD)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 71 interaction(s) predicted by orthology.

Predicted by orthology
Total	71 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004697	protein kinase C activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008047	enzyme activator activity
GO:0016301	kinase activity
GO:0016740	transferase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0019899	enzyme binding
GO:0043560	insulin receptor substrate binding
GO:0046872	metal ion binding

Biological Process

GO:0006468	protein phosphorylation
GO:0006915	apoptotic process
GO:0007049	cell cycle
GO:0016064	immunoglobulin mediated immune response
GO:0016310	phosphorylation
GO:0018107	peptidyl-threonine phosphorylation
GO:0023021	termination of signal transduction
GO:0030837	negative regulation of actin filament polymerization
GO:0032613	interleukin-10 production
GO:0032615	interleukin-12 production
GO:0032930	positive regulation of superoxide anion generation
GO:0034351	negative regulation of glial cell apoptotic process
GO:0035307	positive regulation of protein dephosphorylation
GO:0035556	intracellular signal transduction
GO:0042100	B cell proliferation
GO:0042119	neutrophil activation
GO:0042742	defense response to bacterium
GO:0043407	negative regulation of MAP kinase activity
GO:0046627	negative regulation of insulin receptor signaling pathway
GO:0050732	negative regulation of peptidyl-tyrosine phosphorylation
GO:0051490	negative regulation of filopodium assembly
GO:0090331	negative regulation of platelet aggregation
GO:0090398	cellular senescence
GO:1900163	positive regulation of phospholipid scramblase activity
GO:2000304	positive regulation of ceramide biosynthetic process
GO:2000753	positive regulation of glucosylceramide catabolic process
GO:2000755	positive regulation of sphingomyelin catabolic process
GO:2001022	positive regulation of response to DNA damage stimulus
GO:2001235	positive regulation of apoptotic signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005783	endoplasmic reticulum
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0005911	cell-cell junction
GO:0016363	nuclear matrix
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000008 C2 domain
IPR000719 Protein kinase domain
IPR000961 AGC-kinase, C-terminal
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR014376 Protein kinase C, delta/epsilon/eta/theta types
IPR017892 Protein kinase, C-terminal
IPR020454 Diacylglycerol/phorbol-ester binding
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00168
PF00069
PF07714
PF00130
PF00433

PRINTS

PR00360
PR00109
PR00008

PIRSF

PIRSF000551

SMART

SM00239
SM00133
SM00109
SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References