Version 5.4
| Bos taurus Gene: PRKCD | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| Summary | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| InnateDB Gene | IDBG-645450.3 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Gene Symbol | PRKCD | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Gene Name | protein kinase C delta type | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Synonyms | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Species | Bos taurus | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Ensembl Gene | ENSBTAG00000008719 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Encoded Proteins |
protein kinase C delta type
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| Protein Structure | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| InnateDB Annotation from Orthologs | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Summary |
[Homo sapiens] Following TNF stimulation, PRKCD phosphorylates TRAF2 leading to CHUK (IKK alpha) and IKBKB (IKK beta) recruitment to the TNF receptor
[Homo sapiens] PRKCD is an essential signalling kinase in C-type lectin receptor-mediated innate immunity and host protection. (Demonstrated in mice)
[Mus musculus] Prkcd is an essential signalling kinase in C-type lectin receptor-mediated innate immunity and host protection.
[Mus musculus] Suppression of Prkcd expression inhibited nitric oxide production in activated macrophages.
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| Entrez Gene | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000163932:
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. The protein encoded by this gene is one of the PKC family members. Studies both in human and mice demonstrate that this kinase is involved in B cell signaling and in the regulation of growth, apoptosis, and differentiation of a variety of cell types. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008] |
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| Gene Information | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Genomic Location | Chromosome 22:48307244-48337780 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Strand | Reverse strand | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Band | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 71 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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| Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| NETPATH |
Alpha6Beta4Integrin pathway
EGFR1 pathway
Wnt pathway
TNFalpha pathway
TCR pathway
BCR pathway
IL4 pathway
IL5 pathway
IL6 pathway
Leptin pathway
Prolactin pathway
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| REACTOME |
Calmodulin induced events pathway
CaM pathway pathway
DAG and IP3 signaling pathway
DAP12 signaling pathway
DAP12 interactions pathway
Role of phospholipids in phagocytosis pathway
Interferon gamma signaling pathway
Effects of PIP2 hydrolysis pathway
PLC-gamma1 signalling pathway
EGFR interacts with phospholipase C-gamma pathway
Signaling by EGFR pathway
G alpha (q) signalling events pathway
Gastrin-CREB signalling pathway via PKC and MAPK pathway
G alpha (z) signalling events pathway
PLC beta mediated events pathway
Opioid Signalling pathway
PLCG1 events in ERBB2 signaling pathway
Signaling by ERBB2 pathway
Phospholipase C-mediated cascade pathway
Signaling by FGFR pathway
Downstream signal transduction pathway
Signaling by PDGF pathway
HuR stabilizes mRNA pathway
Apoptotic cleavage of cellular proteins pathway
Apoptotic execution phase pathway
Signaling by FGFR in disease pathway
Signalling by NGF pathway
Signaling by EGFR in Cancer pathway
Downstream signaling of activated FGFR pathway
Signaling by VEGF pathway
Cytokine Signaling in Immune system pathway
Signaling by GPCR pathway
Innate Immune System pathway
Platelet activation, signaling and aggregation pathway
Apoptosis pathway
Signal Transduction pathway
GPCR downstream signaling pathway
Interferon Signaling pathway
G-protein mediated events pathway
Immune System pathway
VEGFR2 mediated cell proliferation pathway
VEGFA-VEGFR2 Pathway pathway
NGF signalling via TRKA from the plasma membrane pathway
Fcgamma receptor (FCGR) dependent phagocytosis pathway
Regulation of mRNA stability by proteins that bind AU-rich elements pathway
Ca-dependent events pathway
Gene Expression pathway
Disease pathway
Hemostasis pathway
Innate Immune System pathway
Apoptosis pathway
Signaling by ERBB2 pathway
PLCG1 events in ERBB2 signaling pathway
GPCR downstream signaling pathway
Disease pathway
Hemostasis pathway
Signaling by GPCR pathway
Role of phospholipids in phagocytosis pathway
Regulation of mRNA stability by proteins that bind AU-rich elements pathway
Ca-dependent events pathway
Signaling by VEGF pathway
Signaling by FGFR in disease pathway
Gastrin-CREB signalling pathway via PKC and MAPK pathway
Cytokine Signaling in Immune system pathway
HuR stabilizes mRNA pathway
VEGFR2 mediated cell proliferation pathway
Apoptotic cleavage of cellular proteins pathway
PLC-gamma1 signalling pathway
Immune System pathway
Platelet activation, signaling and aggregation pathway
EGFR interacts with phospholipase C-gamma pathway
Downstream signal transduction pathway
Downstream signaling of activated FGFR pathway
CaM pathway pathway
Effects of PIP2 hydrolysis pathway
Signaling by EGFR pathway
G alpha (z) signalling events pathway
Interferon gamma signaling pathway
Interferon Signaling pathway
Phospholipase C-mediated cascade pathway
VEGFA-VEGFR2 Pathway pathway
Fcgamma receptor (FCGR) dependent phagocytosis pathway
Signalling by NGF pathway
Gene Expression pathway
Signaling by PDGF pathway
DAG and IP3 signaling pathway
NGF signalling via TRKA from the plasma membrane pathway
G alpha (q) signalling events pathway
Opioid Signalling pathway
Calmodulin induced events pathway
Signal Transduction pathway
Signaling by FGFR pathway
PLC beta mediated events pathway
G-protein mediated events pathway
Signaling by EGFR in Cancer pathway
Apoptotic execution phase pathway
DAP12 interactions pathway
DAP12 signaling pathway
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| KEGG |
GnRH signaling pathway pathway
Fc epsilon RI signaling pathway pathway
Tight junction pathway
Type II diabetes mellitus pathway
Fc gamma R-mediated phagocytosis pathway
Vascular smooth muscle contraction pathway
Neurotrophin signaling pathway pathway
Chemokine signaling pathway pathway
Tight junction pathway
Type II diabetes mellitus pathway
Fc epsilon RI signaling pathway pathway
GnRH signaling pathway pathway
Fc gamma R-mediated phagocytosis pathway
Chemokine signaling pathway pathway
Vascular smooth muscle contraction pathway
Neurotrophin signaling pathway pathway
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| INOH |
IL-7 signaling pathway
JAK STAT pathway and regulation pathway
EPO signaling pathway pathway
FGF signaling pathway pathway
VEGF signaling pathway pathway
GPCR GroupI metabotropic glutamate receptor signaling pathway pathway
NGF signaling pathway pathway
GPCR signaling pathway
IL-7 signaling pathway
JAK STAT pathway and regulation pathway
EPO signaling pathway pathway
FGF signaling pathway pathway
VEGF signaling pathway pathway
GPCR GroupI metabotropic glutamate receptor signaling pathway pathway
NGF signaling pathway pathway
GPCR signaling pathway
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| PID NCI |
Trk receptor signaling mediated by PI3K and PLC-gamma
Syndecan-2-mediated signaling events
Ceramide signaling pathway
Alpha-synuclein signaling
Trk receptor signaling mediated by the MAPK pathway
LPA receptor mediated events
PAR1-mediated thrombin signaling events
ErbB1 downstream signaling
IGF1 pathway
p53 pathway
Signaling events mediated by VEGFR1 and VEGFR2
Syndecan-4-mediated signaling events
Hedgehog signaling events mediated by Gli proteins
Validated transcriptional targets of TAp63 isoforms
PDGFR-beta signaling pathway
IL6-mediated signaling events
IFN-gamma pathway
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| Cross-References | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| SwissProt | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| TrEMBL | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Entrez Gene | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| UniGene | Bt.13142 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| RefSeq | NM_001077855 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| HUGO | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| OMIM | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| CCDS | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| HPRD | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| IMGT | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| EMBL | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| GenPept | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| RNA Seq Atlas | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||