InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: ENPP2

Summary

InnateDB Protein

IDBP-698352.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ENPP2

Protein Name

Ectonucleotide pyrophosphatase/phosphodiesterase family member 2

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000036974

InnateDB Gene

IDBG-645628 (ENPP2)

Protein Structure

UniProt Annotation

Function

Hydrolyzes lysophospholipids to produce lysophosphatidic acid (LPA) in extracellular fluids. Major substrate is lysophosphatidylcholine. Also can act on sphingosylphosphphorylcholine producing sphingosine-1-phosphate, a modulator of cell motility. Can hydrolyze, in vitro, bis-pNPP, to some extent pNP-TMP, and barely ATP. Involved in several motility- related processes such as angiogenesis and neurite outgrowth. Acts as an angiogenic factor by stimulating migration of smooth muscle cells and microtubule formation. Stimulates migration of melanoma cells, probably via a pertussis toxin-sensitive G protein. May have a role in induction of parturition. Possible involvement in cell proliferation and adipose tissue development. Tumor cell motility-stimulating factor (By similarity). {ECO:0000250}.

Subcellular Localization

Secreted. Note=Secreted by most body fluids including serum and CSF. Also by adipocytes and numerous cancer cells (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003824	catalytic activity
GO:0004622	lysophospholipase activity
GO:0005044	scavenger receptor activity
GO:0005509	calcium ion binding
GO:0008270	zinc ion binding
GO:0016787	hydrolase activity
GO:0030247	polysaccharide binding
GO:0046872	metal ion binding
GO:0047391	alkylglycerophosphoethanolamine phosphodiesterase activity

Biological Process

GO:0006629	lipid metabolic process
GO:0006898	receptor-mediated endocytosis
GO:0006935	chemotaxis
GO:0006955	immune response
GO:0008152	metabolic process
GO:0009395	phospholipid catabolic process
GO:0016042	lipid catabolic process
GO:0030334	regulation of cell migration
GO:0034638	phosphatidylcholine catabolic process

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space

Protein Structure and Domains

PDB ID

InterPro

IPR001212 Somatomedin B domain
IPR001604 DNA/RNA non-specific endonuclease
IPR002591 Type I phosphodiesterase/nucleotide pyrophosphatase/phosphate transferase
IPR017850 Alkaline-phosphatase-like, core domain
IPR020436 Somatomedin B, chordata
IPR020821 Extracellular Endonuclease, subunit A

PFAM

PF01033
PF01223
PF01663

PRINTS

PR00022

PIRSF

SMART

SM00201
SM00892
SM00477

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

A1A4K5

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

532663

UniGene

Bt.89258

RefSeq

NP_001073762

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC126631

GenPept

AAI26632