InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: ENPP2

Summary

InnateDB Gene

IDBG-645628.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ENPP2

Gene Name

Ectonucleotide pyrophosphatase/phosphodiesterase family member 2

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000013165

Encoded Proteins

IDBP-698352

Ectonucleotide pyrophosphatase/phosphodiesterase family member 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000136960:
The protein encoded by this gene functions as both a phosphodiesterase, which cleaves phosphodiester bonds at the 5' end of oligonucleotides, and a phospholipase, which catalyzes production of lysophosphatidic acid (LPA) in extracellular fluids. LPA evokes growth factor-like responses including stimulation of cell proliferation and chemotaxis. This gene product stimulates the motility of tumor cells and has angiogenic properties, and its expression is upregulated in several kinds of carcinomas. The gene product is secreted and further processed to make the biologically active form. Several alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2008]
The protein encoded by this gene functions as both a phosphodiesterase, which cleaves phosphodiester bonds at the 5\' end of oligonucleotides, and a phospholipase, which catalyzes production of lysophosphatidic acid (LPA) in extracellular fluids. LPA evokes growth factor-like responses including stimulation of cell proliferation and chemotaxis. This gene product stimulates the motility of tumor cells and has angiogenic properties, and its expression is upregulated in several kinds of carcinomas. The gene product is secreted and further processed to make the biologically active form. Several alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 14:83360211-83456674

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000037135

ENSBTAP00000036974

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003824	catalytic activity
GO:0004622	lysophospholipase activity
GO:0005044	scavenger receptor activity
GO:0005509	calcium ion binding
GO:0008270	zinc ion binding
GO:0016787	hydrolase activity
GO:0030247	polysaccharide binding
GO:0046872	metal ion binding
GO:0047391	alkylglycerophosphoethanolamine phosphodiesterase activity

Biological Process

GO:0006629	lipid metabolic process
GO:0006898	receptor-mediated endocytosis
GO:0006935	chemotaxis
GO:0006955	immune response
GO:0008152	metabolic process
GO:0009395	phospholipid catabolic process
GO:0016042	lipid catabolic process
GO:0030334	regulation of cell migration
GO:0034638	phosphatidylcholine catabolic process

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000136960

View Gene Order

ENSMUSG00000022425

View Gene Order

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

hsa00565

Ether lipid metabolism pathway

mmu00565

Ether lipid metabolism pathway

INOH

INOH website

Nicotinate Nicotinamide metabolism pathway

PID NCI

Cross-References

SwissProt

A1A4K5

TrEMBL

UniProt Splice Variant

Entrez Gene

532663

UniGene

Bt.25525 Bt.89258

RefSeq

NM_001080293 XM_005215666

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC126631

GenPept

AAI26632

RNA Seq Atlas

532663