InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: ALAS1

Summary

InnateDB Protein

IDBP-698418.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ALAS1

Protein Name

5-aminolevulinate synthase, nonspecific, mitochondrial

Synonyms

ALAS-H;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000005380

InnateDB Gene

IDBG-645685 (ALAS1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Mitochondrion matrix {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0003870	5-aminolevulinate synthase activity
GO:0016740	transferase activity
GO:0016746	transferase activity, transferring acyl groups
GO:0030170	pyridoxal phosphate binding

Biological Process

GO:0006778	porphyrin-containing compound metabolic process
GO:0006782	protoporphyrinogen IX biosynthetic process
GO:0006783	heme biosynthetic process
GO:0008152	metabolic process
GO:0009058	biosynthetic process
GO:0033014	tetrapyrrole biosynthetic process

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005759	mitochondrial matrix

Protein Structure and Domains

PDB ID

InterPro

IPR000192 Aminotransferase class V domain
IPR000277 Cys/Met metabolism, pyridoxal phosphate-dependent enzyme
IPR004839 Aminotransferase, class I/classII
IPR010961 Tetrapyrrole biosynthesis, 5-aminolevulinic acid synthase
IPR015118 5-aminolevulinate synthase presequence
IPR015424 Pyridoxal phosphate-dependent transferase

PFAM

PF00266
PF01053
PF00155
PF09029

PRINTS

PIRSF

PIRSF001434

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

A6QLI6