Version 5.4
Bos taurus Gene: ALAS1
Summary
InnateDB Gene IDBG-645685.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ALAS1
Gene Name 5-aminolevulinate synthase, nonspecific, mitochondrial
Synonyms ALAS-H
Species Bos taurus
Ensembl Gene ENSBTAG00000004118
Encoded Proteins
IDBP-698418
5-aminolevulinate synthase, nonspecific, mitochondrial
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000023330:
This gene encodes the mitochondrial enzyme which is catalyzes the rate-limiting step in heme (iron-protoporphyrin) biosynthesis. The enzyme encoded by this gene is the housekeeping enzyme; a separate gene encodes a form of the enzyme that is specific for erythroid tissue. The level of the mature encoded protein is regulated by heme: high levels of heme down-regulate the mature enzyme in mitochondria while low heme levels up-regulate. A pseudogene of this gene is located on chromosome 12. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Dec 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:49242706-49256766
Strand Reverse strand
Band
Transcripts
ENSBTAT00000005380 ENSBTAP00000005380
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Predicted by orthology
Total 13 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0003870 5-aminolevulinate synthase activity
GO:0016740 transferase activity
GO:0016746 transferase activity, transferring acyl groups
GO:0030170 pyridoxal phosphate binding
Biological Process
GO:0006778 porphyrin-containing compound metabolic process
GO:0006782 protoporphyrinogen IX biosynthetic process
GO:0006783 heme biosynthetic process
GO:0008152 metabolic process
GO:0009058 biosynthetic process
GO:0033014 tetrapyrrole biosynthetic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000023330
View Gene Order
ENSMUSG00000032786
View Gene Order
Pathways
NETPATH
REACTOME
REACT_207951
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) pathway
REACT_214581
Transcriptional activation of mitochondrial biogenesis pathway
REACT_210300
Metabolism of porphyrins pathway
REACT_212036
Heme biosynthesis pathway
REACT_219933
Metabolism of lipids and lipoproteins pathway
REACT_219139
Metabolism pathway
REACT_207237
PPARA activates gene expression pathway
REACT_226458
Fatty acid, triacylglycerol, and ketone body metabolism pathway
REACT_205675
Mitochondrial biogenesis pathway
REACT_219259
Organelle biogenesis and maintenance pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_116145
PPARA activates gene expression pathway
REACT_19241
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) pathway
REACT_22279
Fatty acid, triacylglycerol, and ketone body metabolism pathway
REACT_9465
Heme biosynthesis pathway
REACT_200751
Organelle biogenesis and maintenance pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_200788
Mitochondrial biogenesis pathway
REACT_9431
Metabolism of porphyrins pathway
REACT_200608
Transcriptional activation of mitochondrial biogenesis pathway
REACT_111217
Metabolism pathway
REACT_224594
Organelle biogenesis and maintenance pathway
REACT_256522
Fatty acid, triacylglycerol, and ketone body metabolism pathway
REACT_188937
Metabolism pathway
REACT_232291
Metabolism of lipids and lipoproteins pathway
REACT_257219
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) pathway
REACT_203298
Heme biosynthesis pathway
REACT_205251
Transcriptional activation of mitochondrial biogenesis pathway
REACT_198602
PPARA activates gene expression pathway
REACT_233360
Metabolism of porphyrins pathway
REACT_211261
Mitochondrial biogenesis pathway
KEGG
hsa00260
Glycine, serine and threonine metabolism pathway
hsa00860
Porphyrin and chlorophyll metabolism pathway
mmu00260
Glycine, serine and threonine metabolism pathway
mmu00860
Porphyrin and chlorophyll metabolism pathway
INOH
INOH website
Glycine Serine metabolism pathway
PID NCI
hnf3bpathway
FOXA2 and FOXA3 transcription factor networks
Cross-References
SwissProt A6QLI6
TrEMBL
UniProt Splice Variant
Entrez Gene 534286
UniGene Bt.15857
RefSeq NM_001101154 XM_005222863
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC147978
GenPept AAI47979
RNA Seq Atlas 534286

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca