InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GUCY1A2

Summary

InnateDB Protein

IDBP-69859.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GUCY1A2

Protein Name

guanylate cyclase 1, soluble, alpha 2

Synonyms

GC-SA2; GUC1A2;

Species

Homo sapiens

Ensembl Protein

ENSP00000282249

InnateDB Gene

IDBG-69857 (GUCY1A2)

Protein Structure

UniProt Annotation

Function

Has guanylyl cyclase on binding to the beta-1 subunit.Isoform 2 acts as a negative regulator of guanylyl cyclase activity as it forms non-functional heterodimers with the beta subunits.

Subcellular Localization

Cytoplasm.

Disease Associations

Tissue Specificity

Isoform 1 is expressed in fetal brain, liver, colon, endothelium and testis. Isoform 2 is expressed only in liver, colon and endothelium.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.

Experimentally validated
Total	13 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004383	guanylate cyclase activity
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0016849	phosphorus-oxygen lyase activity
GO:0020037	heme binding

Biological Process

GO:0006182	cGMP biosynthetic process
GO:0007165	signal transduction
GO:0007596	blood coagulation
GO:0009190	cyclic nucleotide biosynthetic process
GO:0030828	positive regulation of cGMP biosynthetic process
GO:0035556	intracellular signal transduction

Cellular Component

GO:0005737

cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR001054 Adenylyl cyclase class-3/4/guanylyl cyclase
IPR011644 Heme-NO binding
IPR011645 Haem NO binding associated
IPR024096 NO signalling/Golgi transport ligand-binding domain
IPR029787 Nucleotide cyclase

PFAM

PF00211
PF07700
PF07701

PRINTS

PIRSF

SMART

SM00044

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P33402