InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: GUCY1A2

Summary

InnateDB Gene

IDBG-69857.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GUCY1A2

Gene Name

guanylate cyclase 1, soluble, alpha 2

Synonyms

GC-SA2; GUC1A2

Species

Homo sapiens

Ensembl Gene

ENSG00000152402

Encoded Proteins

IDBP-69859

guanylate cyclase 1, soluble, alpha 2

IDBP-69861

guanylate cyclase 1, soluble, alpha 2

IDBP-589196

guanylate cyclase 1, soluble, alpha 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Soluble guanylate cyclases are heterodimeric proteins that catalyze the conversion of GTP to 3',5'-cyclic GMP and pyrophosphate. The protein encoded by this gene is an alpha subunit of this complex and it interacts with a beta subunit to form the guanylate cyclase enzyme, which is activated by nitric oxide. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
Soluble guanylate cyclases are heterodimeric proteins that catalyze the conversion of GTP to 3\',5\'-cyclic GMP and pyrophosphate. The protein encoded by this gene is an alpha subunit of this complex and it interacts with a beta subunit to form the guanylate cyclase enzyme, which is activated by nitric oxide. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:106674012-107018524

Strand

Reverse strand

Band

q22.3

Transcripts

ENST00000282249	ENSP00000282249
ENST00000347596	ENSP00000344874
ENST00000526355	ENSP00000431245

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.

Experimentally validated
Total	13 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004383	guanylate cyclase activity
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0016849	phosphorus-oxygen lyase activity
GO:0020037	heme binding

Biological Process

GO:0006182	cGMP biosynthetic process
GO:0007165	signal transduction
GO:0007596	blood coagulation
GO:0009190	cyclic nucleotide biosynthetic process
GO:0030828	positive regulation of cGMP biosynthetic process
GO:0035556	intracellular signal transduction

Cellular Component

GO:0005737

cytoplasm

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000041624

View Gene Order

ENSBTAG00000044144

Not yet available

Pathways

NETPATH

REACTOME

REACT_23862

Nitric oxide stimulates guanylate cyclase pathway

REACT_23876

Platelet homeostasis pathway

REACT_604

Hemostasis pathway

KEGG

hsa04540

Gap junction pathway

hsa00230

Purine metabolism pathway

hsa04730

Long-term depression pathway

hsa04270

Vascular smooth muscle contraction pathway

hsa04970

Salivary secretion pathway

INOH

INOH website

Purine nucleotides nucleosides metabolism pathway

PID NCI

Cross-References

SwissProt

P33402

TrEMBL

UniProt Splice Variant

Entrez Gene

2977

UniGene

Hs.603487 Hs.630445

RefSeq

NM_000855 NM_001256424

HUGO

HGNC:4684

OMIM

601244

CCDS

CCDS58170 CCDS8335

HPRD

IMGT

EMBL

AP001282 AP001881 AP003078 AP005014 BC130484 BC130488 BC144033 CH471065 X63282 Z50053

GenPept

AAI30485 AAI30489 AAI44034 CAA44921 CAA90393 EAW67081

RNA Seq Atlas

2977