Version 5.4
Bos taurus Protein: CDC25C
Summary
InnateDB Protein IDBP-698716.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CDC25C
Protein Name M-phase inducer phosphatase 3
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000006968
InnateDB Gene IDBG-645944 (CDC25C)
Protein Structure
UniProt Annotation
Function Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle. When phosphorylated, highly effective in activating G2 cells into prophase. Directly dephosphorylates CDK1 and activate its kinase activity (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 28 interaction(s) predicted by orthology.
Predicted by orthology
Total 28 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004721 phosphoprotein phosphatase activity
GO:0004725 protein tyrosine phosphatase activity
GO:0005515 protein binding
GO:0016787 hydrolase activity
GO:0019901 protein kinase binding
GO:0050699 WW domain binding
Biological Process
GO:0000086 G2/M transition of mitotic cell cycle
GO:0000087 mitotic M phase
GO:0006470 protein dephosphorylation
GO:0007049 cell cycle
GO:0007067 mitotic nuclear division
GO:0035335 peptidyl-tyrosine dephosphorylation
GO:0051301 cell division
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR000751 M-phase inducer phosphatase
IPR001763 Rhodanese-like domain
PFAM PF06617
PF00581
PRINTS PR00716
PIRSF
SMART SM00450
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt A5D7P0
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 507731
UniGene Bt.43933
RefSeq NP_001091465
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC140630
GenPept AAI40631

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca